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Hypertension: more than blood pressure alone.

By Johannes Theodorus Martinus van Leeuwen


Hypertension is a condition not merely characterized by a high blood pressure. In asymptomatic hypertensives, functional and structural cardiovascular abnormalities can be detected. The presence of certain signs of end organ damage has predictive value for the subsequent occurence of cardiovascular disease. Some aspects are described in this thesis. Even in subjects, who show a spontaneous normalization of high blood pressure, functional cardiac abnormalities could be demonstrated. In untreated hypertensives, antihypertensive drugs improved functional and structural hypertension induced cardiovascular abnormalities. A difference in effect between representatives of different classes of antihypertensive drugs could be detected on cardiac structure and 24-hour blood pressure despite comparable office blood pressure reduction. From the results of such small scale studies, drugs can be selected on the basis of their ability to improve subclinical end organ damage and to control blood pressure during daily life. Ultimately, large intervention trials should be initiated to study the impact of treatment of hypertension with drugs, selected in this way, on cardiovascular morbidity and mortality. ... Zie: Summary and conclusions

Topics: Hypertensie, Proefschriften (vorm); 44.85 cardiologie
Year: 1993
OAI identifier: oai:ub.rug.nl:dbi/4942162e45b0a
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