Since the introduction of the immunosuppressive druk ciclosporin A (CsA), the results of virtually all organ transplant programs have shown a tremendous improvement, as illustrated by, a prolonged graft survival, a marked reduction of serious rejection episodes, and a reduction in the number of long term steroid-induced complications. Nevertheless, these improvements have been realized at the expense of newly introduced, CsA-induced side effects. Of which the most important is its nephrotoxicity. ... Zie: Summary and conclusions
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