Cytomegalovirus (CMV) establishes a persistent latent infection in the human host. Healthy individuals rarely suffer from disease symptoms during primary infection nor do they experience symptomatic reactivation of the resident virus. In individuals with a deficient immune system primary infection or reactivation of the virus may lead to serious illness. In most individuals the (deficient) immune system manages to clear the host from an active CMV infection. So far a non-complicated therapy against CMV is not available. ... Zie: Summary.