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Design and Synthesis of Reagents for Phage Display Screening of Dehalogenases

By Roland J. Pieters, Marko Fennema, Richard M. Kellogg and Dick B. Janssen


Bifunctional molecules containing both a biotin and a substrate unit have been designed and synthesized for phage display screening of mutant libraries of haloalkane dehalogenase enzymes. The molecules were assembled using a convergent modular synthetic strategy. One molecule was synthesized to evaluate the concept of covalent capture and a second for screening of phage libraries for enantioselectivity.

Year: 1999
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