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Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution

By Robert M. Haak, Chiara Tarabiono, Dick B. Janssen, Adriaan J. Minnaard, Johannes G. de Vries and Ben L. Feringa


3-Alkenyl and heteroaryl chloroalcohols have been obtained in excellent enantiomeric excess (>99%) by enzymatic kinetic resolution using the haloalcohol dehalogenase HheC. Yields were close to the theoretical maximum for all substrates employed. Furthermore, the applicability of this methodology on multigram scale has been established.

Year: 2007
DOI identifier: 10.1002/chin.200720030
OAI identifier:

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