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Virulence attenuation and phenotypic variation of Paracoccidioides brasiliensis isolates obtained from armadillos and patients

By SAG Macoris, MF Sugizaki, MTS Peraçoli, SMG Bosco, F Hebeler-Barbosa, LB Simões, RC Theodoro, LA Trinca and E Bagagli

Abstract

Paracoccidioides brasiliensis is the etiological agent of paracoccidioidomycosis, the most important systemic mycosis in Latin America. The virulence profiles of five isolates of P. brasiliensis were studied in two different moments and correlated with some colonial phenotypic aspects. We observed a significant decrease in the virulence and an intense phenotypic variation in the mycelial colony. The recognition of all ranges of phenotypic and virulence variation of P. brasiliensis, as well as its physiological and genetic basis, will be important for a better comprehension of its pathogenic and epidemiological features

Topics: Paracoccidioides brasiliensis, virulence, hamster, Dasypus novemcinctus, Microbiology, QR1-502, Science, Q, DOAJ:Microbiology, DOAJ:Biology, DOAJ:Biology and Life Sciences, Arctic medicine. Tropical medicine, RC955-962, Special situations and conditions, RC952-1245, Internal medicine, RC31-1245, Medicine, R, DOAJ:Internal medicine, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Instituto Oswaldo Cruz, Ministério da Saúde
Year: 2006
DOI identifier: 10.1590/S0074-02762006000300019
OAI identifier: oai:doaj.org/article:1ffcd3f4028543a9ba0a2dea0b21e3a1
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