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Epithelial trophoblastic tumor associated with in situ squamous cell carcinoma of the cervix Tumor trofoblástico epitelioide associado a carcinoma epidermoide in situ cervical

By Eduardo Cambruzzi, Karla Lais Pêgas, Dennis Baroni Cruz and Pedro Guilherme Schaefer


Epithelioid trophoblastic tumors are rare neoplasias that develop from the neoplastic transformation of chorionic-type intermediate trophoblasts. They show a wide spectrum of differential diagnoses. The authors describe a case of epithelioid trophoblastic tumor with atypical presentation in a 26-year-old patient that had recently undergone conization for in situ squamous cell carcinoma of the uterine cervix. The histopathology, immunohistochemistry and differential diagnoses of the lesion are also discussed. No similar case had been reported in the medical literature and it is an example of the hindrances to the diagnosis of epithelioid trophoblastic tumors.<br>Os tumores trofoblásticos epitelioides são neoplasias raras que se desenvolvem a partir da transformação neoplásica de trofoblastos intermediários coriônicos, apresentando grande espectro de diagnósticos diferenciais. Os autores descrevem um caso de tumor trofoblástico epitelioide com apresentação atípica em paciente de 26 anos de idade, que apresentava história recente de conização por carcinoma epidermoide in situ do colo uterino. Histopatologia, imuno-histoquímica e diagnósticos diferenciais da lesão também são discutidos. Nenhum caso similar foi descrito na literatura, sendo um exemplo das dificuldades encontradas para diagnosticar os tumores trofoblásticos epitelioides

Topics: Neoplasias ginecológicas, Carcinoma epidermoide, Patologia, Imuno-histoquímica, Gynecological neoplasias, Squamous cell carcinoma, Pathology, Immunohistochemistry, Pathology, RB1-214, Medicine, R, DOAJ:Pathology, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Sociedade Brasileira de Patologia Clínica
Year: 2010
DOI identifier: 10.1590/S1676-24442010000200008
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