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The comparative in vitro and in vivo activity of antilymphocyte serum raised by immunization with thymic, splenic, and lymph node lymphocytes

By K Ono, P Bell, N Kashiwagi and TE Starzl


Rabbit ALS was raised against the splenic, thymic, and lymph node lymphocytes of inbred Fischer rats. The different antisera had the same ability to induce lymphopenia or to protect auxiliary cardiac homografts from rejection after transplantation from Wistar-Furth donors to Fischer recipients. There was a difference in the toxicity of the agents in that the antispleen and antithymus sera caused thrombocytopenia. The severity of this complication seemed related to the degree of platelet contamination of the rat cell suspensions originally given to the rabbits. The thrombocytopenia can be at least partially avoided by cleaning up the immunizing antigen as well as by platelet absorption of the resulting ALS. © 1969

Year: 1969
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Provided by: D-Scholarship@Pitt

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