Skip to main content
Article thumbnail
Location of Repository

Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos

By Erlando Schmidt Jr, Wanessa R Melchert and Fábio R. P Rocha


A flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2'-biquinoline 4,4'-dicarboxylic acid. Linear responses were achieved in the µmol L-1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 µg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level

Topics: flow analysis, pharmaceuticals, sequential determination, Chemistry, QD1-999, Science, Q
Publisher: Sociedade Brasileira de Química
Year: 2011
DOI identifier: 10.1590/S0100-40422011000700019
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • (external link)
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.