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Hiperplasia gengival induzida por ciclosporina A Ciclosporine A-induced gingival hyperplasia

By Vera Lúcia Costa Ramalho, Horácio José Ramalho, José Paulo Cipullo and Emmanuel A. Burdmann

Abstract

O crescente uso da ciclosporina A (CSA) em transplantes de órgãos e no tratamento de doenças auto-imunes aumentou a incidência de seus efeitos adversos, entre eles a hiperplasia gengival (HG). Esta acarreta problemas estéticos, de fala, mastigação e de erupção dentária nos pacientes afetados. A prevalência de hiperplasia gengival induzida por ciclosporina varia nos diversos estudos, podendo chegar a 85%, dependendo do critério utilizado para seu diagnóstico. Esta revisão aborda aspectos etiológicos, histológicos, de quadro clínico, prevenção e tratamento desta importante lesão.<br>The increasing use of cyclosporine A (CSA) in organ transplants and in the treatment of autoimmune diseases has increased the incidence of cyclosporine A-related adverse effects, including gingival hyperplasia (GH). GH causes esthetic, speech, mastication and tooth growth problems in the affected patients. The prevalence of cyclosporine-induced GH varies in different studies and may be as high as 85%, depending on the diagnostic criteria. This review approaches etiological, histological and clinical issues, as well as the prevention and treatment of this important injury

Topics: Ciclosporina A, Toxicidade, Hiperplasia Gengival, Cyclosporine-A, Toxicity, Gingival hyperplasia, Medicine (General), R5-920, Medicine, R, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Associação Médica Brasileira
Year: 2003
DOI identifier: 10.1590/S0104-42302003000200043
OAI identifier: oai:doaj.org/article:be45d849b25f49b7b174a7fff2db11d5
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