Skip to main content
Article thumbnail
Location of Repository

In Vitro Biocompatibility and Mechanical Performance of Titanium Doped High Calcium Oxide Metaphosphate-Based Glasses

By Ensanya A. Abou Neel, Wojciech Chrzanowski, George Georgiou, Matthew J. Dalby and Jonathan C. Knowles

Abstract

This study challenged to produce phosphate-based glasses (PBG) for the treatment of osseous defects. The glasses contained, among other components, 40 mol% CaO and 1–5 mol% TiO2. The mechanical performance and in vitro biocompatibility using both human osteosarcoma and primary osteoblasts were carried out. Incorporation of TiO2 into PBG had no significant effect on strength and modulus. These glasses encouraged attachment and maintained high viability of osteosarcoma cells similar to the positive control surface. Cells grown directly (on glasses) or indirectly (in the presence of glass extracts) showed similar proliferation pattern to the positive control cells with no significant effect of TiO2 detected. Increasing TiO2 content, however, has a profound effect on cytoskeleton organization and spreading and maturation of primary osteoblasts. It is believed that TiO2 might have acted as a chemical cue-modulating cells response, and hence the substrates supported maturation/mineralization of the primary osteoblasts

Topics: Biochemistry, QD415-436
Publisher: SAGE Publishing
Year: 2010
DOI identifier: 10.4061/2010
OAI identifier: oai:doaj.org/article:75bc5e639fc84d40bcad52a3faa98e36
Journal:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://doaj.org/toc/2041-7314 (external link)
  • http://tej.sagepub.com/content... (external link)
  • https://doaj.org/article/75bc5... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.