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Relating a calcium indicator signal to the unperturbed calcium concentration time-course

By Abarbanel Henry DI and Borst Alexander

Abstract

<p>Abstract</p> <p>Background</p> <p>Optical indicators of cytosolic calcium levels have become important experimental tools in systems and cellular neuroscience. Indicators are known to interfere with intracellular calcium levels by acting as additional buffers, and this may strongly alter the time-course of various dynamical variables to be measured.</p> <p>Results</p> <p>By investigating the underlying reaction kinetics, we show that in some ranges of kinetic parameters one can explicitly link the time dependent indicator signal to the time-course of the calcium influx, and thus, to the unperturbed calcium level had there been no indicator in the cell.</p

Topics: Biology (General), QH301-705.5, Science, Q, DOAJ:Biology, DOAJ:Biology and Life Sciences, Computer applications to medicine. Medical informatics, R858-859.7
Publisher: BioMed Central
Year: 2007
DOI identifier: 10.1186/1742-4682-4-7
OAI identifier: oai:doaj.org/article:13f2e7efe1554c48a7fb9279168f8f86
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