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Effect of <it>Kohl-Chikni Dawa </it>– a compound ophthalmic formulation of Unani medicine on naphthalene-induced cataracts in rats

By Zaidi Zehra, Nadeem Ayasha, Iqbal Nishat, Zafar Shadab, Siddiqui Tariq and Alavi Shareef

Abstract

<p>Abstract</p> <p>Background</p> <p>Cataracts are the leading cause of blindness worldwide, accounting for 13-27% of cases. <it>Kohl-Chikni Dawa</it> (KCD) is reputed for its beneficial effects in the treatment of premature cataracts. However, its efficacy is yet to be tested. To investigate the rationality of the therapeutic use of <it>Kohl-Chikni Dawa </it>(<it>KCD</it>) in Unani medicine.</p> <p>Methods</p> <p>The effect of <it>Kohl-Chikni Dawa </it>eye drops on naphthalene-induced cataracts in rats was investigated by slit-lamp biomicroscopic analysis. The normal group of experimental animals was administered with mineral oil (orally), while other groups were given naphthalene (orally) along with local application of <it>KCD </it>eye drops (once and twice daily), placebo and distilled water (twice daily). Initial morphological changes of the lenses were observed twice a week for two weeks, and thereafter once a week for four weeks.</p> <p>Results</p> <p>Local application of <it>KCD </it>(twice daily) caused significant reduction in the lens opacification after 2 to 4 weeks of naphthalene administration.</p> <p>Conclusion</p> <p><it>KCD </it>eye drops may have the potential to delay progression of naphthalene-induced cataracts in rats.</p

Topics: Medicine (General), R5-920, Medicine, R, DOAJ:Medicine (General), DOAJ:Health Sciences, Other systems of medicine, RZ201-999
Publisher: BioMed Central
Year: 2002
DOI identifier: 10.1186/1472-6882-2-13
OAI identifier: oai:doaj.org/article:0d9ab75a8b3c41d5a530fdd87aebad09
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