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Atividade antibacteriana de floroglucinóis e do extrato hexânico de Hypericum brasiliense Choysi Antibacterial activity of the phloroglucinols and hexanic extract from Hypericum brasiliense Choysi

By Hildegardo Seibert França, Ricardo Machado Kuster, Priscila da Nóbrega Rito, Adriana Passos de Oliveira, Lenise Arneiro Teixeira and Leandro Rocha

Abstract

<abstract language="eng">Three phloroglucinols were obtained from Hypericum brasiliense: japonicine A (1), isouliginosin B (2) and uliginosin B (3). Bioautography and disk diffusion methods were used to determine antibacterial activity of the hexanic extract. Strains of the Coagulase Negative Staphylococcus and American Methicillin Resistant Staphylococcus aureus clones showed a growth inhibition zone ranging from 10 to 12 mm and 7 to 15 mm, respectively. Minimal inhibitory concentration (MIC) values were used to measure antistaphylococcal activity for all phloroglucinols. Isouliginosin B and uliginosin B presented MIC values of 1.5 and 3.0 µg/mL, respectively, while japonicine A displayed MIC value of 50.0 µg/mL

Topics: Hypericum brasiliense, antibacterial activity, phloroglucinol, Chemistry, QD1-999, Science, Q, DOAJ:Chemistry (General), DOAJ:Chemistry
Publisher: Sociedade Brasileira de Química
Year: 2009
DOI identifier: 10.1590/S0100-40422009000500004
OAI identifier: oai:doaj.org/article:020451647c5c4484b3a3d110c16a19ad
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