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A first case of protease codon 35 amino acid insertion in a HIV-1 subtype B sequence detected in the Bauru region, state of São Paulo, Brazil: case report

By Rejane Maria Tommasini Grotto, Sílvia Maria Corvino, Lilian da Silva Reis Munhoz, Cibele Gomes Ghedini and Maria Inês de Moura Campos Pardini

Abstract

Amino acid insertions in the protease have rarely been described in HIVinfected patients. One of these insertions has recently been described in codon 35, although its impact on resistance remains unknown. This study presents a case of an HIV variant with an insertion in codon 35 of the protease, described for the first time in Bauru, State of Sao Paulo, Brazil, circulating in a 38-year-old caucasian male with asymptomatic HIV infection since 1997. The variant isolated showed a codon 35 insertion of two amino acids in the protease: a threonine and an aspartic acid, resulting in the amino acid sequence E35E_TD

Topics: Codon 35 da protease, HIV, Inserção, Medicine (General), R5-920, Medicine, R, Arctic medicine. Tropical medicine, RC955-962
Publisher: Sociedade Brasileira de Medicina Tropical (SBMT)
Year: 2011
DOI identifier: 10.1590/S0037-86822011000300027
OAI identifier: oai:doaj.org/article:2baa9b79ef7a43cbaa0a98ed1e55840f
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