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Neuro-inflammation, blood-brain barrier, seizures and autism

By Theoharides Theoharis C and Zhang Bodi

Abstract

<p>Abstract</p> <p>Many children with Autism Spectrum Diseases (ASD) present with seizure activity, but the pathogenesis is not understood. Recent evidence indicates that neuro-inflammation could contribute to seizures. We hypothesize that brain mast cell activation due to allergic, environmental and/or stress triggers could lead to focal disruption of the blood-brain barrier and neuro-inflammation, thus contributing to the development of seizures. Treating neuro-inflammation may be useful when anti-seizure medications are ineffective.</p

Topics: Autism, Blood-Brain Barrier, Mast cells, Neuroinflammation, Flavonoids, Medicine (General), R5-920, Medicine, R, DOAJ:Medicine (General), DOAJ:Health Sciences, Neurology. Diseases of the nervous system, RC346-429, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Internal medicine, RC31-1245, DOAJ:Neurology
Publisher: BioMed Central
Year: 2011
DOI identifier: 10.1186/1742-2094-8-168
OAI identifier: oai:doaj.org/article:3a91b07e283746edbe77fa7974027ad5
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