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Detection and Discrimination of Non-Melanoma Skin Cancer by Multimodal Imaging

By Jürgen Popp, Benjamin Dietzek, Jürgen Lademann, Hans-Joachim Röwert-Huber, Franziska Kluschke, Tobias Meyer, Denis Akimov, Sandro Heuke and Nadine Vogler

Abstract

Non-melanoma skin cancer (NMSC) belongs to the most frequent human neoplasms. Its exposed location facilitates a fast ambulant treatment. However, in the clinical practice far more lesions are removed than necessary, due to the lack of an efficient pre-operational examination procedure: Standard imaging methods often do not provide a sufficient spatial resolution. The demand for an efficient in vivo imaging technique might be met in the near future by non-linear microscopy. As a first step towards this goal, the appearance of NMSC in various microspectroscopic modalities has to be defined and approaches have to be derived to distinguish healthy skin from NMSC using non-linear optical microscopy. Therefore, in this contribution the appearance of ex vivo NMSC in a combination of coherent anti-Stokes Raman scattering (CARS), second harmonic generation (SHG) and two photon excited fluorescence (TPEF) imaging—referred as multimodal imaging—is described. Analogous to H&E staining, an overview of the distinct appearances and features of basal cell and squamous cell carcinoma in the complementary modalities is derived, and is expected to boost in vivo studies of this promising technological approach

Topics: CARS, TPEF, SHG, multimodal imaging, coherent Raman scattering, skin cancer, basal cell carcinoma, squamous cell carcinoma, non-melanoma skin cancer, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9, Internal medicine, RC31-1245, Medicine, R, DOAJ:Internal medicine, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: MDPI AG
Year: 2013
DOI identifier: 10.3390/healthcare1010064
OAI identifier: oai:doaj.org/article:3ba4058a5306435393b1f7e62fbe1559
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