Objective: This study was conducted to evaluate the antimicrobial activities of Lenzites betulinus and Coriolopsis gallica extracts against some bacterial isolates of medical importance. The organisms are Pseudomonas aeruginosa, Staphylococcus aureus, Proteus vulgaris, Klebsiella pneumonia and Escherichia coli. Methods: Agar well diffusion assay was used, the ethanolic, petroleum ether and aqueous extract of C. gallica was assayed against the bacterial isolates. Results: Petroleum ether extract of C. gallica and L. betulinus was able to inhibit P. vulgaris with inhibition zones of 26.0 mm and 20.0 mm respectively. Ethanolic extract of C. gallica also inhibited P. vulgaris with inhibition zone of 22.0 mm while aqueous extract and petroleum ether of L. betulinus inhibited P. aeruginosa with inhibition zones of 20.0 mm and 23.0 mm respectively. E. coli and S. aureus were also inhibited by the aqueous and ethanolic extract of L. betulinus with zones of inhibition 15.0 mm and 26.0 mm against E. coli while 19.0 mm and 22.0 mm against S. aureus respectively. This study also showed the presence of some phytochemicals like tannins, phenolics, flavonoids, steroids and saponin in the mushrooms with antimicrobial effects against the bacterial isolates used. The active components present in ethanolic, aqueous and petroleum ether extracts of C. gallica include phenolics, flavonoids and steroids while phytochemicals obtained from L. betulinus are phenolics, tannins, flavonoids and saponin respectively. Conclusion: The efficacy of these mushrooms as antimicrobial agents was attributed to the presence of various photochemicals present; hence they could be used in the simulation of drugs against some multi resistant strain of microorganisms. [TAF Prev Med Bull 2012; 11(6.000): 695-698
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