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Experimental nodel of C6 brain tumors in athymic rats Modelo experimental de tumor cerebral C6 em ratos atímicos

By Flávio K. Miura, Maria José Ferreira Alves, Mussya Cisotto Rocha, Roseli S. Silva, Sueli M. Oba-Shinjo, M. Uno, C. Colin, M.C. Sogayar and Sueli K.N. Marie

Abstract

Malignant brain tumor experimental models tend to employ cells that are immunologically compatible with the receptor animal. In this study, we have proposed an experimental model of encephalic tumor development by injecting C6 cells into athymic Rowett rats, aiming at reaching a model which more closely resembles to the human glioma tumor. In our model, we observed micro-infiltration of tumor cell clusters in the vicinity of the main tumor mass, and of more distal isolated tumor cells immersed in normal encephalic parenchyma. This degree of infiltration is superior to that usually observed in other C6 models.<br>Modelos experimentais de tumores cerebrais malignos geralmente utilizam células imunologicamente compatíveis com o animal receptor. Neste estudo apresentamos um modelo experimental baseado na inoculação de células C6 em ratos atímicos Rowett, visando obter um tumor que se assemelhe mais àqueles observados nos seres humanos. Neste modelo observamos microinfiltração de ilhotas de células na periferia da massa tumoral principal e nas áreas mais distantes, células tumorais isoladas no tecido cerebral normal. Este grau de infiltração é superior àquele observado em outros modelos utilizando as células C6

Topics: tumor cerebral, células C6, modelo experimental, glioma, brain tumor, C6 cells, experimental model, glioma, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Internal medicine, RC31-1245, Medicine, R, DOAJ:Neurology, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: Academia Brasileira de Neurologia (ABNEURO)
Year: 2008
DOI identifier: 10.1590/S0004-282X2008000200019
OAI identifier: oai:doaj.org/article:3cbe59d4ba994853b1a35c1e3e0912be
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