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HIV - recentes avanços na pesquisa de fármacos HIV - highlights in drug research

By Wilson Cunico, Claudia R. B. Gomes and Walcimar T. Vellasco Junior

Abstract

<abstract language="eng">The development of new antiretroviral drugs is a dynamic process that is continuously fueled by identification of new molecular targets and new compounds for know targets. The current available drugs can be classified into five categories: nucleoside analogues reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, protease inhibitors, integrase inhibitors and entry inhibitors (fusion inhibitors and CCR5 antagonist). In addition, the maturation inhibitors may be considered as potential target for chemotherapeutic intervention. This review presents some anti-HIV agents that have already gone through the advance development process for final approval for the treatment of AIDS

Topics: anti-HIV drugs, AIDS, new drugs, Chemistry, QD1-999, Science, Q, DOAJ:Chemistry (General), DOAJ:Chemistry
Publisher: Sociedade Brasileira de Química
Year: 2008
DOI identifier: 10.1590/S0100-40422008000800035
OAI identifier: oai:doaj.org/article:3cc243e2c6484f9087fcc27d02bc5dc8
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