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Chemical Genetics of Acetyl-CoA Carboxylases

By Xuyu Zu, Jing Zhong, Dixian Luo, Jingjing Tan, Qinghai Zhang, Ying Wu, Jianghua Liu, Renxian Cao, Gebo Wen and Deliang Cao


Chemical genetic studies on acetyl-CoA carboxylases (ACCs), rate-limiting enzymes in long chain fatty acid biosynthesis, have greatly advanced the understanding of their biochemistry and molecular biology and promoted the use of ACCs as targets for herbicides in agriculture and for development of drugs for diabetes, obesity and cancers. In mammals, ACCs have both biotin carboxylase (BC) and carboxyltransferase (CT) activity, catalyzing carboxylation of acetyl-CoA to malonyl-CoA. Several classes of small chemicals modulate ACC activity, including cellular metabolites, natural compounds, and chemically synthesized products. This article reviews chemical genetic studies of ACCs and the use of ACCs for targeted therapy of cancers

Topics: acetyl-CoA carboxylase, fatty acid biosynthesis, ACC chemical genetics, ACC inhibitors, cancer therapy, Organic chemistry, QD241-441, Chemistry, QD1-999, Science, Q, DOAJ:Organic Chemistry, DOAJ:Chemistry
Publisher: MDPI AG
Year: 2013
DOI identifier: 10.3390/molecules18021704
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