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Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?

By Frankland Paul W, Sakaguchi Masanori and Arruda-Carvalho Maithé

Abstract

<p>Abstract</p> <p>Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the adult hippocampus, raising the possibility that disrupted adult neurogenesis lies at the core of this and other psychiatric disorders.</p

Topics: Neurology. Diseases of the nervous system, RC346-429, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Internal medicine, RC31-1245, Medicine, R, DOAJ:Neurology, DOAJ:Medicine (General), DOAJ:Health Sciences
Publisher: BioMed Central
Year: 2008
DOI identifier: 10.1186/1756-6606-1-5
OAI identifier: oai:doaj.org/article:39450df0b0384f0c9d06630863e0ef62
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