Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

Abstract

The nuclear factor-jB (NF-jB) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-jB pathway, namely the IjB kinasesubunits(IKKa,IKKbandNEMO),theIjB proteins(IjBa,IjBb,IjBeandBcl-3)andthefiveNF-jB transcription factors (NF-jB1, NF-jB2, c-Rel, RelA and RelB),havebeengeneticallymanipulatedusingtransgenic andknockouttechnology