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NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory

By B J Saab, J Georgiou, A Nath, F J Lee, M Wang, A Michalon, F Liu, I M Mansuy and J C Roder

Abstract

The molecular underpinnings of exploration and its link to learning and memory remain poorly understood. Here we show that inducible, modest overexpression of neuronal calcium sensor 1 (Ncs1) selectively in the adult murine dentate gyrus (DG) promotes a specific form of exploratory behavior. The mice also display a selective facilitation of long-term potentiation (LTP) in the medial perforant path and a selective enhancement in rapid-acquisition spatial memory, phenotypes that are reversed by direct application of a cell-permeant peptide (DNIP) designed to interfere with NCS-1 binding to the dopamine type-2 receptor (D2R). Moreover, the DNIP and the D2R-selective antagonist L-741,626 attenuated exploratory behavior, DG LTP, and spatial memory in control mice. These data demonstrate a role for NCS-1 and D2R in DG plasticity and provide insight for understanding how the DG contributes to the origin of exploration and spatial memory acquisition

Topics: Brain Research Institute, 570 Life sciences; biology, 610 Medicine & health
Publisher: Elsevier
Year: 2009
DOI identifier: 10.1016/j.neuron.2009.08.014
OAI identifier: oai:www.zora.uzh.ch:24269
Provided by: ZORA
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