Factors Affecting the Vitamin K Requirement of the Chick

Abstract

(1944) reported that sulfaguanidine, sulfa-pyrazine, sulfadiazine, sulfathiazole and sulfaquinoxaline induced vitamin K de-ficiency in rats and dogs. Asplin and Boy-land (1947) found that sulfamethazine in-creased the blood clotting time of chicks and that this effect was overcome with vitamin K. Farr and Jaquette (1947) re-ported that chicks six weeks of age were more susceptible to the toxic effects of sulfamethazine than those 2-4 weeks old. Delaplane and Milliff (1948) observed hemorrhages of the legs and lesions of the liver, spleen, heart and lungs of pullets fed sulfaquinoxaline. Shelton el al. (1954