canSAR: an integrated cancer public translational research and drug discovery resource

Abstract

canSAR is a fully integrated cancer research and drug discovery resource developed to utilize the growing publicly available biological annotation, chemical screening, RNA interference screening, ex-pression, amplification and 3D structural data. Scientists can, in a single place, rapidly identify bio-logical annotation of a target, its structural charac-terization, expression levels and protein interaction data, as well as suitable cell lines for experiments, potential tool compounds and similarity to known drug targets. canSAR has, from the outset, been completely use-case driven which has dramatically influenced the design of the back-end and the func-tionality provided through the interfaces. The Web interface a