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Characterisation of a recombinant human cysteine dioxygenase

By Christopher Harper Barry

Abstract

Cysteine Dioxygenase is an enzyme that catalyses the reaction of cysteine to cysteinesulfinic acid and is thought to regulate the intracellular concentrations of its substrate. The enzyme may also be involved in the oxidation of exposed sulfidrils of protein and by implication, involved in cell signalling or regulation. Substrate and products of cysteine dioxygenase are known to be disrupted in a number of neurodegenerative diseases making the protein an important target for medical research. To date, the structure of the protein has not been solved. An understanding of its structure and reaction mechanism will further the understanding of the aetiology of a number of different pathologies. Its structure may also further the development of novel pharmacological drugs

Topics: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Year: 2003
OAI identifier: oai:etheses.bham.ac.uk:1483

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  1. Alterations in glutathione levels in parkinson's disease and other neurodegenerative disorders affecting basal ganglia doi
  2. (1998). Alzheimer's peptide abetal-42 binds to two beta-sheets of alpha 1-antichymotrypsin and transforms it from inhibitor to substrate. doi
  3. (1980). Attempt to demonstrate virus interference in cell cultures persistently infected with the viruses of kuru and creutzfeldt-jacob disease.
  4. (1999). Increased basal ganglia iron levels in huntington disease. doi
  5. (1999). Mitochondrial involvement in parkinson's disease, huntington's disease, hereditary spastic paraplegia and friedreich's ataxia [see commentsl. doi
  6. (1997). Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in alzheimer's disease.
  7. (2000). Prion protein gfycosylation is sensitive to redox change [pub lished erratum appears in j biol chem
  8. (1999). Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity. doi
  9. (1976). Purification and some properties of rat liver cysteine oxidase (cysteine dioxygenase). Btochim Biophys Acta, doi
  10. (1982). Purification of prions from scrapie infected hamster brain...

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