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SERUM Β2-MICROGLOBULIN LEVELS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS OF RECENT ONSET

By ΠΑΝΑΓΙΩΤΑ ΤΣΕΡΠΕ

Abstract

SERUM LEVELS OF Β2-MICROGLOBULIN (Β2-Μ) WERE MEASURED BY NEPHELΟMETRY IN 45 PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) OF RECENT ONSET (DISEASE DURATION EQUAL TO OR LESS THAN ONE YEAR) AND WITHOUT RENAL INVOLVEMENT, WHO MET THE ARA CRITERIA FOR CLASSIFICATION OF SLE (GROUP I) AND IN 14 OF THESE PATIENTS AT A TIME WHEN THEIR MEAN DISEASE DURATION WAS 5 MONTHS AND THE CLINICAL DIAGNOSIS OF SLE WAS DONE WHILE THESE PATIENTS DID NOT FULFILL THE ABOVE CRITERIA (GROUP II). TWENTY FIVE PATIENTS WITH RHEUMATOID ARTHRITIS (RA) OF RECENT ONSET AS DETERMINED ABOVE AND 30 HEALTHY SUBJECTS WERE INCLUDED IN THE STUDY AS CONTROL GROUPS. OUR OBSERVATORY SUGGEST THAT Β2 SERUM LEVELS ARE NOT HELPFUL IN THEDIFFERENTIAL DIAGNOSIS OF SLE AND RA OF RECENT ONSET. HOWEVER, OUR FINDINGS ARE SUGGESTIVE THAT INCREASED Β2 IN SERUM LEVELS MAY BE OF VALUE IN THE DIAGNOSTIC APPROACH OF SLE WITHOUT RENAL INVOLVEMENT, ESPECIALLY DURING ITS EARLY STAGES, AS WELL AS IN THE ASSESSMENT OF SLE DISEASE ACTIVITY.

Topics: SERUM Β2 MICROGLOBULIN, Systemic lupus erythematosus ( SLE), β_2 Microglobulin, Συστηματικός ερυθηματώδης λύκος ( ΣΕΛ)
Publisher: National and Kapodistrian University of Athens
Year: 1996
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