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THE ANTIINFLAMMATORY ACTION OF MAGNESIUM IONS ON THE ALLERGIC CONTACT DERMATITIS

By ΔΗΜΗΤΡΙΟΣ ΔΟΥΣΗΣ

Abstract

IN THIS STUDY WE EXAMINED THE INFLUENCE OF MAGNESIUM IONS ON THE ALLERGIC CONTACT DERMATITIS. WE USED 48 MALE MICE IATROGENIC SENSITIZED WITH DINITROCHLOROBENZENE (DNCB). THE TEST PERFORMED WAS THE MOUSE EAR SWELLING TEST (MEST). THEREWAS MEASURED WITH PRECISIONS MICROMETER THE ANTIINFLAMMATORY ACTION OF MAGNESIUM, AT THE START OF THE ELICITATION PHASE OF THE ALLERGIC CONTACT DERMATITISWITH DNCB AND MAGNESIUM AND AT THE SECOND PART OF THE ELICITATION PHASE WITHCOMPLETE DEVELOPMENT OF THE INFLAMMATION. THE RESULTS DEMONSTRATED A STATISTICALLY SIGNIFICANT (P < 0,001) ANTIINFLAMMATORY ACTION AT THE TWO PARTS OF THEEXPERIMENTS. PERSPECTIVELY MAGNESIUM COULD BE USED FOR THE PREVENTION AND TREATMENT OF THE ALLERGIC CONTACT DERMATITIS, AS WELL AS SUPPORTING THE THERAPYOF OTHER INFLAMMATORY DERMATOSES.

Topics: Allergic contact dermatitis, ANTIINFLAMMATORY ACTION, DINITROCHLOROBENZENE, Magnesium, Αλλεργική δερματίτιδα εξ επαφής, Αντιφλεγμονώδης δράση, ΔΙΝΙΤΡΟΧΛΩΡΟΒΕΝΖΟΛΙΟ, Μαγνήσιο
Publisher: National and Kapodistrian University of Athens
Year: 1993
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