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LECTIN BINDING TO PRECANCEROUS LESIONS OF THE STOMACH AND EARLY GASTRIC CANCERS

By ΙΩΑΝΝΑ ΓΚΙΚΟΝΤΗ

Abstract

LECTINS' BINDING IN THE EARLY GASTRIC CARCINOMA AND PRECANCEROUS LESIONS WAS INVESTIGATED IN 30 PATIENTS. THE AIM OF THE STUDY WAS THE LECTINS' BINDING PROFILE DETERMINATION, BETWEEN THE NORMAL AND PATHOLOGICAL GASTRIC MUCOSAL CELLS. THE INDIRECT IMMUNOHISTOCHEMICAL METHOD (PAP) WAS PERFORMED, BY MEANS OF THE USE OF THE FOLLOWING LECTINS: PNA, WGA, UEA1 AND PHA-L. NEURAMINIDASE DIGESTIONWAS APPLIED SELECTIVELY AS WELL. IT WAS CONCLUDED THAT AT THE NORMAL GASTRIC MUCOSA THE BINDING OF THE LECTINS USED VARIES IN EITHER INTENSITY OR EXTENSION. AT THE PATHOLOGICAL EPITHELIUM (METAPLASTIC, DYSPLASTIC, CARCINOMATOUS) AN UNHOMOGENEOUS REACTION AND HETEROGENIC BINDING WAS OBSERVED, DEPENDING ON THE LECTIN USED, THE SEVERITY OF THE LESION AND THE GRADE OF THE TUMOR. THESE FINDINGS SUGGEST THAT THE LECTINS USED, REPRESENT MARKERS VALUABLE FOR THE DIAGNOSIS OF THE EARLY GASTRIC CARCINOMA.

Topics: ATROPHIC GASTRITIS, Early gastric cancer, EPITHELIAL DYSPLASIA, GLYCOCONJUGATES OF GASTRIC MUCOSA, Intestinal metaplasia, Lectins, ΑΡΧΟΜΕΝΟ ΓΑΣΤΡΙΚΟ ΚΑΡΚΙΝΩΜΑ, ΑΤΡΟΦΙΚΗ ΓΑΣΤΡΙΤΙΔΑ, ΓΛΥΚΟΠΡΩΤΕΙΝΕΣ ΓΑΣΤΡΙΚΟΥ ΒΛΕΝΝΟΓΟΝΟΥ, ΕΝΤΕΡΙΚΗ ΜΕΤΑΠΛΑΣΗ, ΕΠΙΘΗΛΙΑΚΗ ΔΥΣΠΛΑΣΙΑ, Λεκτίνες
Publisher: National and Kapodistrian University of Athens
Year: 1986
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