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HLA-A, B, C AND DR ANTIGENS IN RECURRENT ORAL ULCERATION

By ΕΛΕΝΗ ΑΛΜΠΑΝΙΔΟΥ-ΦΑΡΜΑΚΗ

Abstract

A STUDY OF THE FREQUENCY OF HLA-A1B1C AND DR ANTIGEΝS WAS PERFORMED IN 106 GREEK PATIENTS AFFECTED FROM RECURRENT ORAL ULCERATION (ROU) AND 120 MATCHED CONTROLS OF THE SAME NATIONALITY. THIS INVESTIGATION REVEALED THAT HLA-DRS ANTIGEN IS MORE FREQUENT IN PATIENTS (PC < 0,01) AND THUS IT MAY BE CONSIDERED AS A GENETIC MARKER OF THE DISEASE IN GREEK POPULATION. STATISTICALLY INCREASED WERE ALSO FOUND HLA-A28 (PC < 0,05) AND HLA-CW2 (PC <0,05) BUT HLA-DR4 WAS FOUNDSTATISTICALLY SIGNIFICANT DECREASED (PC < 0,05) IN PATIENTS WITH ROU. AS A GENERAL APPROACH WE MAY POSTULATE THAT GENETIC FACTORS CLOSELY RELATED WITH HLA SYSTEM PLAY A RATHER IMPORTANT ROLE IN THE DEVELOPMENT OF RECURRENT ORAL ULCERATION.

Topics: ANTIGEN FREQUENCY, HLA-ANTIGENS, HLA-ΑΝΤΙΓΟΝΑ, MHC-MAJOR HISTOCOMPATIBILITY COMPLEX, RECURRENT ORAL ULCERATION, ΑΝΤΙΓΟΝΙΚΗ ΣΥΧΝΟΤΗΤΑ, ΑΠΛΟΤΥΠΙΚΗ ΣΥΧΝΟΤΗΤΑ, Μείζον σύστημα ιστοσυμβατότητας, ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ
Publisher: Aristotle University Of Thessaloniki (AUTH)
Year: 1986
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