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KEFTRIAXONE PENETRATON IN TO PROSTATE

By ΙΩΑΝΝΗΣ ΣΤΑΥΡΙΝΑΔΗΣ

Abstract

CEFTRIAXONE, A NEW SEMISYNTHETIC PARENTERAL CEPHALOSPORIN WITH HIGH ACTIVITY AGAINST BOTH GRAM POSITIVE AND NEGATIVE ORGANISMS WAS FOUND TO HAVE UNIQUE PHARMACOKINETIC PROPERTIES WHICH ALLOWS ONCE A DAY ADMINISTRATION. CLINICAL TRIALSSHOWED ITS EXCELLENT CLINICAL EFFICACY AND SAFETY AND ALSO ITS LACK OF TOXICITY. WE USED CEFTRIAXONE IN 21 ELDERLY PATIENTS WHO WERE ADMITTED TO THE UROLOGY DEPARTMENT OF THE UNIVERSITY OF IOANNINA FOR PROSTATECTOMY. AFTER ONE SIHALE2 G I.V. ADMINISTRATION OF CEFTRIAXONE IN EACH PATIENT PROSTATECTOMY WAS PERFORMED AT 1, 2, 4, 8, 12 AND 24 HOURS IN GROUPS OF PATIENTS (3 OR 6 PATIENTS IN EACH GROUP). TO STUDY CEFTRIAXONE BLOOD CONCENTRATION THREE BLOOD SAMPLES WERE OBTAINED FROM EACH PATIENT IN DIFFERENT TIME INTERVALS. THE ASSAY OF BLOOD AND TISSUE CONCENTRATIONS WERE PERFORMED BY A BIOLOGICAL METHOD. BLOOD CONCENTRATIONS RANGED FROM 49,0 TO 100,0 MG/ML AT ONE HOUR AFTER ADMINISTRATION, WHILE THEY RANGED FROM 2,6 TO 28,0 MG/ML AT 24 HOURS. THESE CONCENTRATIONS ARE BACTERICIDAE FOR MOST SUSCEPTIBLE PATHOGENS. PROSTATIC TISSUE CONCENTRATIONS WERE FOUND IN A RANGE OF 14,9 TO 73,7 MG/ML AT ONE HOUR (M.V.: 28,9+- 22,3) AND I, 3 TO 2,0 MG/ML AT 24 H. THESE CONCENTRATIONS ARE ALSO BACTERICIDAE FOR MOST SUSCEPTIBLE TO CEFTRIAXONE ORGANISMS. SERUM AND PROSTATIC TISSUE CEFTRIAXONE HALF-LIVES WERE CALCULATED TO BE ABOUT THE SAME (6,8 HOURS). THESE FINDINGS SUGGESTS THAT CEFTRIAXONE COULD BE PROVED EFFECTIVE IN TREATING BACTERIAE INFECTIONS IN THE PROSTATIC GLAND.

Topics: ANTIBIOTIC, Ceftriaxone, Cephalosporin, Pathology, PENETRATON, Physiology, PROSTATE ANATOMY, Prostatitis, Therapy, Αντιβιοτικά, Διείσδυση, ΘΕΡΑΠΕΙΑ ΠΡΟΣΤΑΤΙΤΙΔΩΝ, Κεφαλοσπορίνη, Κεφτριαξόνη, Παθολογία, ΠΡΟΣΤΑΤΗΣ ΑΝΑΤΟΜΙΑ, Προστατίτιδα, Φυσιολογία
Publisher: University of Ioannina
Year: 1986
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