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Studies of Muscle Capillary Basement Membranes in Normal Subjects, Diabetic, and Prediabetic Patients

By M. D. Siprsbmn, R. H. Unger and L. L. Madison

Abstract

measurement of muscle capillary basement mem-branes by electron microscopic examination of needle biopsies of the quadriceps muscle. With this procedure it has been possible to obtain an ob-jective evaluation of the significance of capillary basement membrane hypertrophy in diabetic mi-croangiopathy. The results *of such studies of muscle capillary basement membrane thickness in 50 normal, 51 diabetic, and 30 prediabetic pa-tients have demonstrated the following. First, that the average capillary basement membrane width of diabetic patients is over twice that of normal subjects; moreover, such basement membrane thickening is a very constant finding among overtly diabetic patients, in that approximately 98%o of individual diabetic subjects demonstrated this lesion. The degree of basement membrane thickening in diabetic patients is, however, un-related to age, weight, severity, or duration of diabetes. Second, capillary basement membrane hypertrophy has been found in approximately 50%o of patients who are genetically prediabetic but who have not yet demonstrated evidence of the manifest carbohydrate disturbances of dia-betes mellitus. Third, in contrast to the results obtained in genetically diabetic patients, subjects with severe hyperglycemia due to causes othe

Year: 2016
OAI identifier: oai:CiteSeerX.psu:10.1.1.928.6268
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