Multiple biomarker use for detection of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome

Abstract

various pathophysiologic pathways to determine their relationships with adverse outcomes in patients pre-senting with symptoms of acute coronary syndrome. Methods: We obtained plasma specimens from 457 patients on admission and measured 7 biomarkers: myeloperoxidase (MPO), soluble CD40 ligand (CD40L), placental growth factor (PlGF), metalloproteinase-9 (MMP-9), high-sensitivity C-reactive protein (hsCRP), cardiac troponin I (cTnI), and N-terminal pro-B-type natriuretic peptide (NT-proBNP). We used the Modifi-cation of Diet in Renal Disease formula to calculate the estimated glomerular filtration rate (eGFR). Endpoints were cardiac events (myocardial infarction, percutane-ous coronary intervention, coronary artery bypass graft, cardiac death) and all-cause mortality. We estimate