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The anterior pituitary response to a gonadotropin-releasing hormone challenge test in normal older reproductive-age women

By William J. Bremner, David E. Battaglia, Michael R. Soules, Victor Y. Fujimoto and Nancy A. Klein


OBJECTIVE: To assess the pituitary responsiveness to GnRH stimulation of premenopausal women relative to age. DESIGN: Older and younger reproductive-age women underwent the GnRH stimulation test in the early follicular phase of the menstrual cycle. SETTING: Female subjects in an academic research environment. PATIENTS: Women aged 21 to 44 years consisting of normal volunteers and infertility patients. INTERVENTIONS: Gonadotropin-releasing hormone was administered intravenously between days 2 and 4 of the menstrual cycle. Blood samples were collected from -20 minutes before to 120 minutes after administration. MAIN OUTCOME MEASURE: Luteinizing hormone, FSH, inhibin, and E2 levels. RESULTS: No significant difference in baseline values existed between older and younger women with regard to LH, inhibin, and E2, but basal FSH levels were higher in older women. A significantly diminished percent of LH and percent FSH change above baseline occurred 30 minutes after GnRH administration in the older women compared with younger women. No change in inhibin or E2 levels could be detected during the sampling period. CONCLUSIONS: The present study demonstrates marked attenuation of the acute pituitary LH response (sensitivity) to GnRH stimulation in older women when compared with a younger cohort.

Topics: reproductive aging, GnRH stimulation test, gonadotropins, Middle Aged, Maternal Age, Pituitary Gland, Anterior, drug effects, secretion, Reference Values, Ovary, drug effects, Adult, Gonadorelin, diagnostic use, Research Support, U.S. Gov't, P.H.S., Time Factors, Chorionic Gonadotropin, therapeutic use, Pregnancy, High-Risk, Infertility, Female, blood, diagnosis, physiopathology, Luteinizing Hormone, blood, secretion, Humans, Female, Follicle Stimulating Hormone, blood
Publisher: Elsevier
Year: 1996
DOI identifier: 10.1016/s0015-0282(16)58150-3
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