NaHSO4/SiO2: An Efficient Catalyst for the Synthesis of β-Enaminones and 2-Methylquinolin-4(1H)-Ones under Solvent-Free Condition

Abstract

ABSTRACT. An efficient and simplified protocol for NaHSO4/SiO2 catalyzed solvent-free synthesis of β-enaminone and 2-methyl-quinolin-4(1H)-one derivatives under microwave irradiation is described. A series of functionalized derivatives have been syn-thesized in shorter reaction times with moderate to good yields. The use of milder catalyst in non-conventional method offers signi-ficant advantages over conventional methods, such as higher selectivities, simplicity, solvent-free reaction and non-environmental polluting conditions