The work in this thesis has been done mainly during the period of registration. No part of this work has been submitted in previous application for a higher degree. I have performed all the work towards this thesis except where assistance has been acknowledged. Assistance during exercise tests has been provided by Kamal Flora, Linzy Houchen and Carolyn Sandland and during the muscle biopsy procedures by Rachael Evans and Sarah Deacon. I give consent for this thesis to be made available for consultation, photocopying and use through other libraries either directly or via the British Lending Library. Signature
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