Effects of acetaminophen and ibuprofen on renal function in the stressed kidney

Abstract

renal function in the stressed kidney. J. Appl. Physiol. 86(2): 598–604, 1999.—Exercise, salt restriction, and/or dehydra-tion causes transient reductions in renal function that may be buffered by vasodilatory prostaglandins (PGs). Over-the-counter (OTC) analgesics have the potential to alter renal hemodynam-ics by inhibiting renal PGs. Therefore, we tested the renal effects of the maximal recommended dose of acetaminophen (Acet, 4 g/day) and ibuprofen (Ibu, 1.2 g/day) vs. a placebo (Pl) in humans subjected to progressive renal stresses. After baseline measurements, 12 fit young (25 6 1 yr) men and women underwent 3 days of a low (10 meq/day)-sodium diet while taking one of the drugs or Pl (crossover design). Day 4 involved dehydration (21.6 % body wt) followed by 45 min of treadmill exercise (65 % maximal O2 uptake) in the heat (36°C). These combined stressors caused dramatic decrease