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BRIEF COMMUNICATIONS and CASE REPORTS Immunohistochemical Detection of Virulence-associated Antigens of Rhodococcus e4ui in Pulmonary Lesions of Foals

By H. Madarame, S. Takai, N. Morisawa, M. Fujii, D. Hidaka, S. Tsubaki and Y. Hasegawa


Abstract. Rhodococcus equi was isolated from the lungs of six foals with bronchopneumonia. All isolates expressed 15-1 7-kd antigens by immunoblot analysis and contained a virulence-associated plasmid of 85 or 90 kb. Immunohistochemically, R. equi from all pulmonary lesions showed the expression of 15-17-kd antigens mainly in the phagocytic cells. The specific monoclonal antibody to 15-17-kd antigens of R. equi (MAb 10G5) may be an aid in the diagnosis of R. equi-induced pneumonia. Key words: Horses; immunohistochemistry; lung; Rhodococcus equi. Rhodococcus equi is an important gram-positive pathogen in foals <6 months old that causes suppurative broncho-pneumonia with abscessation, ulcerative enterocolitis, and occasionally other systemic lesions.1,2,5 This ubiquitous dis-ease has a mortality rate of 4O-8O0/o2 and reportedly accounts for more than 3 % of all foal deaths4 The pathogenesis of R. equi infection in foals remains unexplained, although there have been several reports about virulence factors associated with R. equi infection.’as Re

Year: 2016
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