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Calcium alginate gels in oral dosage form design

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Graduation date: 1991In vivo research following ingesting of commercially available\ud Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of\ud Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose\ud of four tablets daily, showed serum lipoprotein concentrations did not\ud change significantly. In order to increase the number of viable\ud Lactobacillus bacteria after challenging in low pH solution (gastric\ud fluid), enteric coating polymer was applied over dried calcium alginate\ud beads containing Lactobacillus. Survival of Lactobacillus bacteria was\ud generally higher from freeze dried calcium alginate beads compared to\ud vacuum dried products. However, after pretreatment with simulated\ud gastric fluid (pH = 1.5) for 2 hours, only the coated products from\ud vacuum drying showed promising results. Lactobacillus bacteria were\ud fully protected against gastric pH after formulating the bacteria inside\ud mini-tablets which were coated with Eudragit L30D, an enteric coating\ud polymer.\ud Alginic acids are naturally occurring substances found only in the\ud brown seaweeds. Alginic acid salts formed with most di-, and polyvalent\ud metals are insoluble in water. The most common application of alginate\ud precipitation in drug product formulation is based on insolubilization\ud of alginate by addition of calcium salt. By altering the composition of\ud calcium alginate, drug loading, enteric coating thickness, and sustained\ud release coating thickness, the lag time for drug dissolution can be\ud controlled. This formulation research provides oral dosage form design\ud for targeted delivery of drug to any desired site in the\ud gastrointestinal tract. Examples of site specific targeted delivery are\ud given for Lactobacillus bacteria, ibuprofen, sulfasalazine, and\ud 5-aminosalicylic acid

Year: 1990
OAI identifier: oai:ir.library.oregonstate.edu:1957/37470
Provided by: ScholarsArchive@OSU

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  1. 1972.Lactic acid bacteria in food and'health: a review with special reference to enteropathogenic Escherichia coli as well as certain enteric diseases and their treatment with antibiotics and
  2. (1987). 5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and protitis.
  3. (1987). 5-Aminosalicylic acid enemas in refractory distal ulcerative colitis: Long-term results.
  4. (1982). 5-Aminosalicylic acid in a slow-release preparation: Bioavailability, plasma level, and excretion in humans.
  5. (1986). A clinical pharmacologic study of 5-aminosalicylic acid oral dosage forms. Gastroenterology 90:1351.
  6. (1982). A delivery system for an active ingredient and a process for preparation thereof.
  7. (1989). A double-blind placebo-controlled comparison of the efficacy and safety of 50, 100, and 200 ug of misoprostol QID in the prevention of ibuprofen-induced gastric and duodenal mucosal lesions and symptoms.
  8. (1977). A factor in milk which influences cholesteremia in rats.
  9. (1982). A method of encapsulating oils and oilsoluble materials.
  10. (1985). A new slowrelease form of 5-aminosalicylic acid for the oral treatment of inflammatory bowel disease.
  11. (1979). A P.M.R. study of the composition and sequence of uronate residues in algintaes.
  12. (1966). A study of constitution of alginic acid by partial acid hydrolysis.
  13. (1985). A sustained release drug delivery system using calcium alginate beads. Drug Dev.
  14. (1972). Absorption, metabolism, and excretion of salicylazosulfapyridine in man.
  15. (1982). Adherence of Lactobacillus species to human fetal intestinal cells.
  16. (1990). Advances in drug therapy for inflammatory bowel disease.
  17. (1973). Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype.
  18. (1979). Alternations in peptidoglycan chemical composition associated with rod-to-sphere transition in a conditional mutant of Klebsiella pneumoniae.
  19. (1977). An experiment to determine the active therapeutic moiety of sulphasalazine. Lancet
  20. (1982). An oral preparation to release drugs in the human colon.
  21. (1984). Applications of immobilized lactic acid bacteria.
  22. (1985). Assimilation of cholesterol by Lactobacillus Acidophilus.
  23. (1986). Azodisal sodium in the treatment of ulcerative colitis.
  24. (1976). B-complex vitamins in cultured and acidified yogurt.
  25. (1981). Calcium-induced alteration of cellular morphology affecting the resistance of Lactobacillus acidophilus to freezing.
  26. (1987). Calciuminduced gelation of alginic acid and pH-sensitive reswelling of dried gels.
  27. (1966). Catabolism and elimination of cholesterol in germfree rats.
  28. (1986). Cellular damage in dried Lactobacillus acidophilus.
  29. (1986). Characterization of Nitrobacter agilis immobilized in calcium alginate. Enzyme Microb.
  30. (1978). Chiroptical and stoichiometric evidence of a specific, primary diverisation process in alginate gelation.
  31. (1987). Coated oral 5-aminosalicylic acid therapy for mildly to moderately active ulcerative colits.
  32. (1980). Colonic N-acetylation of 5-aminosalicylic acid in inflammatory bowel disease.
  33. (1983). Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis.
  34. (1983). Comparative study of the efficiency of some additives in protecting lactic acid bacteria against freeze-drying.
  35. (1988). Comparison of delayed-release 5-aminosalicylic acid (Mesalazine) and sulfasalazine as maintenance treatment for patients with ulcerative colitis.
  36. (1984). Comparison of immobilization methods for plant cells and protoplasts.
  37. (1984). Comparison of the absorption and metabilism of sulphasalazine and acrylic-coated 5-amino salicylic acid in normal subjects and patients with colitis.
  38. (1982). Controllrd release of the herbicides 2,4 D and dichlobenil from alginate gels.
  39. (1987). Correlation of ibuprofen bioavailability with gastrointestinal transit by scintigraphic monitoring of 71Er- labeled sustainedrelease tablets.
  40. (1972). Death of Lactobacillus bulgaricus resulting from liquid nitrogen freezing.
  41. (1977). Deconjugation of Bile acids by intestinal Lactobacilli.
  42. (1980). Denitrification of water using immobilized Pseudomonas denitrificans cells.
  43. (1983). Diffusion of oxygen in alginate gels related to the kinetics of methanol oxidation by immobilized Hansenula polymorpha cells.
  44. (1973). Distribution studies of salicylazosulfapyridine and its metabilites.
  45. (1985). Drug delivery to the proxinal colon.
  46. (1978). Effect of a lactobacilli preparation on traveller's diarrhea. A randomized, double blind clinical trial. Gastroenterology 74:829.
  47. (1986). Effect of aqueous phase modifiers on drug release from polyacrylamide microbeads.
  48. (1984). Effect of consuming yogurts prepared with three culture strains on human serum lipoproteins.
  49. (1980). Effect of diet and Lactobacillus acidophillus supplements on human fecal bacterial enzymes.
  50. (1985). Effect of drying medium on residual moisture content and viability of freeze-dried lactic acid bacteria.
  51. (1986). Effect of perorally administered lactobacilli on macrophage activation in mice.
  52. (1987). Effect of polymer coating on faecal recovery of ingested 5-aminosalicylic acid in patients with ulcerative colitis.
  53. (1987). Effective diffusion coefficients in calcium alginate gel.
  54. (1981). Electron microscopic evidence of an immobilized living cell system. Enzyme Microb.
  55. (1969). Electron microscopic study of membranes and walls of bacteria and changes occurring during growth initiation.
  56. (1988). Elie Metchnikoff's bacillus of long life.
  57. (1974). Enterotoxinproducing Escherichia coli and diarrheal disease in adult travelers: a prospective study.
  58. (1977). Enumeration and identity of lactobacilli in dietary products.
  59. (1985). Evaluation of solid dispersed particles for formulation of oral ibuprofen tablets.
  60. (1986). Factors affecting the growth characteristics of alginate-entrapped Chlorella. Enzyme Microb.
  61. (1960). Factors affecting the viability of air-borne bacteria. III. The role of bonded water and protein structure in the death of air-borne cells.
  62. features and structural variations.
  63. (1983). Free and toatl area/dose relationship.
  64. (1989). Freeze-drying injury of Lactobacillus acidophilus.
  65. (1966). Freezing and drying of bacteria. in Cryobiology.
  66. (1989). Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects.
  67. (1989). Gastrointestinal transit of non-disintegrating tablets in fed subjects.
  68. (1987). Gel formulations for the treatment of pruning wounds. I. Carbendazim and triadimefon in sodium alginate.
  69. (1987). Gel formulations for the treatment of pruning wounds. II. Results with differing gel and fungicide components and comparison witn sealant compositions.
  70. (1984). Generic tolbutamide tablet dissolution: Intralot and interlot variation.
  71. (1980). HPLC analysis of sulphasalazine and its metabolites.
  72. (1974). Human intestinal flora.
  73. (1979). Hypocholesterolemic effect of yogurt and milk.
  74. (1980). Immobilization and mechanical support of individual protoplasts.
  75. (1984). Immobilization of plant protoplasts.
  76. (1986). Immobilization of yeast cells by internal gelation of alginate. Enzyme Microb.
  77. (1987). Immobilized cells: a review of recent literature. Enzyme Microb.
  78. (1985). Immobilized plant cells: Respiration and oxygen transfer.
  79. (1982). Immobilized plant cells. in Advances in Applied Microbiology.
  80. (1987). Impact of Lactobacillus supplements on the human oropharyngeal and intestinal microflora.
  81. (1973). in Low Temperature Preservation of Foods and Living Material.
  82. (1986). In vitro evaluation of alginate gel systems as sustained release drug delivery systems.
  83. (1986). Influence of alginate properties on sucrose inversion by immobillized whole cell invertase. Enzyme Microb.
  84. (1978). Influence of consuming nonfermented milk containing Lactobacillius acidophilus on fecal flora of healthy males.
  85. (1987). Influence of surfactant on the properties of granules and tablets containing sodium alginate.
  86. (1982). Isolation of an inhibitor of hepatic cholesterolgenesis from human milk.
  87. (1981). Lack of serum cholesterol-lowering effect of skimmed milk and butter milk under controlled conditions. Atherosclerosis 39:267.
  88. (1986). Lactobacillus acidophilus strains of bacteria and compositions thereof.
  89. Lactobacillus effects on cholesterol: In vitro and in vivo results.
  90. (1985). Liquid penetration into tablets containing surfactants.
  91. (1973). Lowering of serum cholesterol by intestinal bacteria in cholesterol-fed piglets. Lipids 8:428.
  92. (1983). Maintenance of remission in ulcerative colitis with 5-amino salicylic acid in high doses by nouth.
  93. (1987). Metabolism and urinary excretion of 5-amino salicylic acid in healthy volunteers when given intravenously released for absorption at different sites in the gastrointestinal tract.
  94. (1988). Method for the preparation of stabile microencapsulated lactic acid bacteria.
  95. (1980). Microencapsulated islets as bioartificial endocrine pancreas.
  96. (1983). Microencapsulation of erythrocytes in Eudragit-RL coated calcium alginate.
  97. (1972). Natural Chelating Polymers: Alginic acid, Chitin and Chitosan. Pergamon Press.
  98. (1988). New enema treatments for inflammatory bowel disease.
  99. (1989). Newer 5-aminosalicylic acid based drugs in Chronic inflammatory bowel disease.
  100. (1987). Nutritional and therapeutic aspects of Lactobacillus acidophilus in dairy products. Cultured Dairy Products
  101. (1984). Oleaginous compositions.
  102. (1987). On the elimination of artefactual effects in assessing the structure of calcium alginate cell immobilization gels. Enzyme Microb.
  103. (1985). Optimization of microencapsulation parameters: Semipermeable microcapsules as a bioartificial pancreas.
  104. (1977). Optimum survival conditions for lactic acid bacteria in spray-dried yoghurt.
  105. (1984). Perspectives in intestinal microecology.
  106. (1988). pharmacokinetics of ibuprofen enantiomers in humans following oral administration of tablets with different absorption rates.
  107. (1984). Pharmacokinetics of ibuprofen in man IV: Absorption and disposition.
  108. (1984). Pharmacokinetics of ibuprofen.
  109. (1987). Pharmacology and pharmacokinetics of 5-aminosalicylic acid.
  110. (1985). Physiology of alginate immobilized Chlorella. Enzyme Microb.
  111. (1981). Powdered milk production.
  112. (1984). Preparation and evaluation of controlled release formulations of 2,6 dichlorobenzonitrile.
  113. (1980). Preparation of immobilized animal cells.
  114. (1972). Preparation of water-soluble glycuronans and their calcium salts, and the determination of calcium ion activity in relation to the degree of polymerization.
  115. (1976). Preservation of mixed species lactic starter concentrates by freezing and lyophilization methods.
  116. (1983). Prevalence of viable lactobacillus acidophilus in dried commercial products.
  117. (1976). Prevention of Vascular complications of diabetes by pancreatic islet Transplantation.
  118. (1984). Production of nikkomycin by immobilized Streptomyces cells physiological properties.
  119. (1984). Prolonged survival of transplanted of langerhans encapsulated in a biocompatible membrane.
  120. (1972). Properties of poly (1,4 hexuronates) in the gel state. II. Comparison of gels of different chemical composition.
  121. (1983). Protective effect of adonitol on lactic acid bacteria subjected to freeze-drying.
  122. (1989). Recent advances in pharmacotherapy: Inflammatory bowel disease.
  123. (1986). Release characteristics of herbicides from Ca alginate gel formulations.
  124. (1987). Role of the intestinal flora in the acetylation of sulfasalazine metabolites.
  125. (1979). Roles of Lactobacillus in the intestinal tract.
  126. (1987). Safe formulations of agrochemicals.
  127. (1986). Salicylates for the sulfa-sensitive patient with ulcerative colitis?.
  128. (1985). Scanning electron microscopic examination of calcium alginate beads immobilizing growing mycelia of Aspergillus phoenicus. Enzyme Microb.
  129. (1977). Secondary and tertiary structure of polysaccharides in solutions and gels.
  130. (1975). Serum cholesterol and bowel flora in the newborn.
  131. (1982). Serum cholesterol levels in rats fed skim milk fermented by Lactobacillus Acidophilus.
  132. (1986). Slow release solid preparation. European Patent Application 0,188,040 Al.
  133. (1979). Small bowel absorption of sulfasalazine and its hepatic metabolism in human beings, cats, and rats.
  134. (1961). Some factors affecting preservability of freeze-dried bacteria.
  135. (1978). Some studies on the use of alginates for the placement and controlled release of diquat on submerged aquatic plants.
  136. (1989). Spherical agglomerates of waterinsoluble drugs.
  137. (1975). Stabilized dry cultures of lactic acid-producing bacteria.
  138. (1985). Stereoselective disposition of ibuprofen enantiomers in
  139. (1974). Studies of a surfactant and cholesteremia in the Maesai.
  140. (1982). Studies on the characteristics of alginate gels in relation to their use in separation and immobilization applications.
  141. (1975). Study of the rate of regression of the glomerular lesions in diabetic rats treated with pancreatic islet transplantation.
  142. (1975). Sucrose inversion by immobilized yeast cells in a complete mixing reactor.
  143. (1986). Sulfasalazine and new analogues.
  144. (1987). Sulfasalazine and related new drugs.
  145. (1988). Sulfasalazine inhibits folate absorption.
  146. (1988). sulfasalazine: I. An historical perspective.
  147. (1988). Sulfasalazine: II. Some notes on the discovery and development of salazopyrin.
  148. (1987). Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells.
  149. (1979). Survival of Lactobacillus acidophilus in a spray-drying process.
  150. (1987). Survival of Lactobacillus acidophilus in blended - spray dried acidophilus preparations.
  151. (1983). Survival of Lactobacillus bulgaricus during freezing and freeze-drying after growth in the presence of calcium.
  152. (1983). Survival rate of salmonella and shigella in fermented milk products with and without added human gastric juice. An in vitro study.
  153. (1983). The effect of acidophilus milk in the treatment of constipation in hospitalized geriatric patients. Nutrition and the intestinal flora. pp.131 in Symp.
  154. (1982). The effect of fermented and unfermented milks on serum cholesterol.
  155. (1990). The effect of food on gastrointestinal (GI) transit of sustained-release ibuprofen tablets as evaluated by gamma scintigraphy.
  156. (1958). The effect of residual water on the survival of dried bacteria during storage.
  157. (1981). The effect of skim milk, yoghurt and full cream milk on human serum lipids.
  158. (1981). The fate of ingested lactobacilli in the proximal small intestine.
  159. (1984). The formation of inclusion compounds of alginic acid in aqueous solution.
  160. (1978). The hypocholesterolemic effect of milk a review.
  161. (1969). The pharmacological properties of ibuprofen, an anti-inflammatory analgesic and antipyretic agent.
  162. (1988). The relationship between plasma ibuprofen concentrations and toxicity in acute ibuprofen overdose. Human Toxicol.
  163. (1972). The role of intestinal bacteria in the metabolism of salicylazosulfapyridine.
  164. (1985). The spreading of foam and solution enemas.
  165. (1967). The structure of alginic acid.
  166. (1980). Therapeutic efficacy of sulfasalazine and its metabolites in patients with ulcerative colitis and Crohn's disease.
  167. (1986). Transit of pharmaceutical dosage forms through the small intestine.
  168. (1976). Traveler's diarrhea in Mexico.
  169. (1983). Treatment of Crohn's disease with peroral 5-aminosalicylic acid.
  170. (1981). Treatment of ulcerative colitis with high-dose 5-aminosalicylic acid enemas. Lancet
  171. (1983). Whole body, liver and plasma cholesterol levels in rats fed Thermophilus, Bulgaricus and Acidophilus milks.

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