This article deals with applying the knowledge production function approach to the measuring and the comparison of the quality of regional innovation systems. It is argued that an embeddedness in a well-functioning innovation system should result in a relatively high propen-sity to innovate and a high productivity of efforts in research and development (R&D). Based on data for eleven European regions, the author has found a number of such statistically significant differences between the manufacturing firms in these regions. Interregional differences in the productivity of R&D activities correspond to some degree with a center-periphery paradigm, which can be found in the literature. Obviously, there exist considerable agglomeration econo-mies that are conducive to R&D activities. LOCATION AND RESEARCH AND DEVELOPMENT ACTIVITIES The notion of a regional innovation system is based on the assumption that loca-tion and spatial proximity matter for innovation activities (Cooke, Uranga, and Etxebarria 1997; Cooke 1998). There have been a number of approaches to investi-gate the impact of regional conditions on the innovation of research and develop-ment (R&D) activities of private firms empirically. However, most attempts tha
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