Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk

Abstract

Several different genetic variants at chromosome 8q24 have been related to prostate, breast and colorectal cancer risk with evidence of region-specific risk differentials for various tumor types. We investigated the association between 15 polymorphisms located in 8q24 regions associated with cancer risk in a pooled analysis of 2587 colorectal adenoma cases, 547 colorectal cancer cases and 2798 controls of European des-cent from four studies. Logistic regression was used to estimate odds ratios (ORs) and 95 % confidence inter-vals (95 % CIs) for the associations. Three polymorphisms (rs10808555, rs6983267 and rs7837328) located between 128.47 and 128.54 Mb were found to be associated with colorectal tumor risk. The association was strongest for the previously reported rs6983267 variant and was similar for both adenoma (ORper allele 5 1.16, 95 % CI: 1.07–1.25, P 5 0.0002) and cancer (OR per allele 5 1.17, 95 % CI: 1.01–1.35, P 5 0.03). The strength of the association of the regional haplotype containing variant alleles at rs10808555