Radiation and reaction at one loop

We study classical radiation fields at next-to-leading order using the methods of scattering amplitudes. The fields of interest to us are sourced when two massive, point-like objects scatter inelastically, and can be computed from one-loop amplitudes. The real and imaginary parts of the amplitudes play important but physically distinct roles in the radiation field. We argue that the imaginary part captures the effects of radiation reaction. This aspect of radiation reaction is directly linked to cuts of one-loop amplitudes which expose Compton trees. We also discuss the fascinating interplay between renormalisation, radiation reaction and classical field theory from this perspective

Monitoring SARS-CoV-2 IgA, IgM and IgG antibodies in dried blood and saliva samples using antibody proximity extension assays (AbPEA)

Using a modified proximity extension assay, total and immunoglobulin (Ig) class-specific anti-SARS-CoV-2 antibodies were sensitively and conveniently detected directly from & oslash;1.2 mm discs cut from dried blood and saliva spots (DBS and DSS) without the need for elution. For total Ig detection, antigen probes were prepared by conjugating recombinant spike protein subunit 1 (S1-RBD) to a pair of oligonucleotides. To detect isotype-specific antibody reactivity, one antigen probe was replaced with oligonucleotide-conjugated antibodies specific for antibody isotypes. Binding of pairs of oligonucleotide-conjugated probes to antibodies in patient samples brings oligonucleotides in proximity. An added DNA polymerase uses a transient hybridization between the oligonucleotides to prime synthesis of a DNA strand, which serves as a DNA amplicon that is quantified by real-time PCR. The S1-RBD-specific IgG, IgM, and IgA antibodies in DBS samples collected over the course of a first and second vaccination exhibited kinetics consistent with previous reports. Both DBS and DSS collected from 42 individuals in the autumn of 2023 showed significant level of total S1-RBD antibodies with a correlation of R = 0.70. However, levels in DSS were generally 10 to 100-fold lower than in DBS. Anti-S1-RBD IgG and IgA in DSS demonstrated a correlation of R = 0.6

Adverse Contagion? : Populist Radical Right Parties and Norms on Gender Balance in Political Institutions

How do male-dominated populist radical right (PRR) parties relate to and influence norms around women’s political inclusion and leadership in mainstream political parties? While research has focused on describing the male dominance of PRR parties or its influence on mainstream political parties’ policies, particularly immigration, we know less about how PRR parties relate to norms on women’s inclusion or gender-balanced representation in mainstream parties. In a theory-building effort, we posit that PRR parties may seek to (a) adapt to mainstream parties’ norms and include more women in leading positions (positive contagion) or (b) negatively affect or even challenge norms around women’s inclusion in mainstream parties (adverse contagion). Seeking to theorize this relationship further, we explore leadership selection in the Swedish Parliament, where gender balance constitutes a strong norm. Yet, following the 2022 elections, the proportion of women parliamentary leaders dipped below 30% for the first time in decades. At the same time, the Sweden Democrats, a male-dominated PRR party, emerged as the second-largest party in Parliament. Drawing on interviews with nomination committees, party documents, and data on leadership, we empirically investigate continuity and change in committee leadership appointments in the Swedish Parliament and the role of the radical right in this process. We do not find signs of adverse contagion in the short run: as of 2023, norms promoting gender balance appear to remain robust and enjoy widespread support among mainstream parties. Yet, neither do we find signs of positive contagion where the radical right adapts to mainstream norms around gender balance

Structure-based virtual screening of vast chemical space as a starting point for drug discovery

Structure-based virtual screening aims to find molecules forming favorable interactions with a biological macromolecule using computational models of complexes. The recent surge of commercially available chemical space provides the opportunity to search for ligands of therapeutic targets among billions of compounds. This review offers a compact overview of structure-based virtual screens of vast chemical spaces, highlighting successful applications in early drug discovery for therapeutically important targets such as G protein-coupled receptors and viral enzymes. Emphasis is placed on strategies to explore ultra-large chemical libraries and synergies with emerging machine learning techniques. The current opportunities and future challenges of virtual screening are discussed, indicating that this approach will play an important role in the next-generation drug discovery pipeline

Associations between alcohol use and outcome of psychological treatment in specialist psychiatric care : a cohort study

BACKGROUND: Alcohol-related issues are widespread worldwide and are fairly substantial. Numerous studies have identified and clarified the effects and prevalence of alcohol use across different contexts. However, when it comes to the prevalence of alcohol in psychiatry and its impact on treatment outcomes compared to other patient groups, studies are relatively scarce, and results often vary, sometimes with different outcomes. This study focuses on investigating the effectiveness of psychological treatment in psychiatric clinics for outpatients, considering those with and without hazardous alcohol use under naturalistic conditions. METHODS: Patients were recruited between 2012 and 2016 from psychiatric clinics in Sormland, Sweden, as part of the regular services. Patients completed symptom assessment instruments regarding depression, anxiety, quality-of-life, and alcohol consumption at the beginning of their psychological treatment, upon completion, and during a follow-up 1 year after completion. Completion of questionnaires was ongoing for some patients until 2021. A total of 324 patients were included in the study, distributed among 59 participating therapists. RESULTS: Among all patients in the study, 30.2% showed hazardous alcohol use at the start of their psychological treatment, with a higher proportion being men. There was a significant reduction in the proportion of patients with hazardous use and a notable decrease in the mean audit score upon completion of psychological treatment. At follow-up, there was no significant change compared to completion. There were 31.2% of the patients who achieved recovery or improvement in the audit score upon completion of treatment. Patients with hazardous alcohol use consistently scored higher mean values on the symptom assessment instruments and lower on the quality-of-life instrument at the beginning. More individuals with hazardous alcohol use typically achieved better results across all outcome instruments at both at completion and follow-up. CONCLUSION: Patients with hazardous alcohol use demonstrate significant improvements in their alcohol consumption through standard psychological treatment in psychiatry, despite the treatment not specifically focusing on alcohol consumption. The progress/improvement appears to be largely maintained at follow-up. Moreover, patients with hazardous alcohol use tend to show greater progress across all outcome instruments. No significant gender differences were detected in this context

Big ideas, soft governance : managing large-scale school improvement at the national agency level in Sweden

Purpose Using a large-scale school improvement program in Sweden as a case, this article aims to explore the state governance of a large-scale school improvement program in Sweden and how officials at the state agency level made sense of the reform ideas and operationalized them in policy actions. Design/methodology/approach Data were integrated from Swedish Government Official Reports and formal directives from the Ministry of Education. Officials of the Swedish National Agency for Education (SNAE) were also interviewed. Data were analyzed to identify how regulatory rules, professional norms and cultural–cognitive beliefs shaped SNAE's design of the program. Findings The article shows how different types of governance (i.e. regulatory rules, professional norms and cultural–cognitive beliefs) set the direction for managing large-scale school improvement. In particular, in the studied case, the lack of clear regulatory directives enabled sensemaking processes clearly influenced by normative ideas and cultural–cognitive beliefs. Research limitations/implications The findings are mostly presented from the perspective of managers, so further study is required to attain a broader understanding of the state agency level's role and function. Practical implications By illustrating the strengths of understanding various dimensions of educational governance, the findings are highly relevant to both policymakers and educational managers at different levels of school systems. Originality/value The article offers a valuable perspective on large-scale school improvement and educational governance by focusing on a level that has hitherto received little attention.The authors contributed equally</p

Mediterranean Diet Adherence and Risk of All-Cause Mortality in Women

Importance Higher adherence to the Mediterranean diet has been associated with reduced risk of all-cause mortality, but data on underlying molecular mechanisms over long follow-up are limited. Objectives To investigate Mediterranean diet adherence and risk of all-cause mortality and to examine the relative contribution of cardiometabolic factors to this risk reduction. Design, Setting, and Participants This cohort study included initially healthy women from the Women's Health Study, who had provided blood samples, biomarker measurements, and dietary information. Baseline data included self-reported demographics and a validated food-frequency questionnaire. The data collection period was from April 1993 to January 1996, and data analysis took place from June 2018 to November 2023. Exposures Mediterranean diet score (range, 0-9) was computed based on 9 dietary components. Main Outcome and Measures Thirty-three blood biomarkers, including traditional and novel lipid, lipoprotein, apolipoprotein, inflammation, insulin resistance, and metabolism measurements, were evaluated at baseline using standard assays and nuclear magnetic resonance spectroscopy. Mortality and cause of death were determined from medical and death records. Cox proportional hazards regression was used to calculate hazard ratios (HRs) for Mediterranean diet adherence and mortality risk, and mediation analyses were used to calculate the mediated effect of different biomarkers in understanding this association. Results Among 25 315 participants, the mean (SD) baseline age was 54.6 (7.1) years, with 329 (1.3%) Asian women, 406 (1.6%) Black women, 240 (0.9%) Hispanic women, 24 036 (94.9%) White women, and 95 (0.4%) women with other race and ethnicity; the median (IQR) Mediterranean diet adherence score was 4.0 (3.0-5.0). Over a mean (SD) of 24.7 (4.8) years of follow-up, 3879 deaths occurred. Compared with low Mediterranean diet adherence (score 0-3), adjusted risk reductions were observed for middle (score 4-5) and upper (score 6-9) groups, with HRs of 0.84 (95% CI, 0.78-0.90) and 0.77 (95% CI, 0.70-0.84), respectively (P for trend &lt; .001). Further adjusting for lifestyle factors attenuated the risk reductions, but they remained statistically significant (middle adherence group: HR, 0.92 [95% CI, 0.85-0.99]; upper adherence group: HR, 0.89 [95% CI, 0.82-0.98]; P for trend = .001). Of the biomarkers examined, small molecule metabolites and inflammatory biomarkers contributed most to the lower mortality risk (explaining 14.8% and 13.0%, respectively, of the association), followed by triglyceride-rich lipoproteins (10.2%), body mass index (10.2%), and insulin resistance (7.4%). Other pathways, including branched-chain amino acids, high-density lipoproteins, low-density lipoproteins, glycemic measures, and hypertension, had smaller contributions (&lt;3%). Conclusions and Relevance In this cohort study, higher adherence to the Mediterranean diet was associated with 23% lower risk of all-cause mortality. This inverse association was partially explained by multiple cardiometabolic factors

Micrometric thermal electronic nose able to detect and quantify individual gases in a mixture

Recent urbanization and environmental problems urge for networks of sensors that can monitor air quality. Small, inexpensive, and smart sensors are one of the key components enabling the realization of such networks. Chemoresistive sensors are the ideal candidate, but they greatly lack selectivity, and for this reason they are usually combined in arrays to create electronic noses, whose dimensions, however, make them not miniaturizable and cannot be integrated into portable devices. To overcome this inconvenience, we present a thermal electronic nose consisting of identical resistive sensors working at different temperatures, so that the whole device is simple to make and tiny. The device contains two sensor arrays based on tin oxide nanowires decorated with Ag and Pt nanoparticles, respectively. The five sensors in each array are identical, but their response is differentiated by different temperatures locally generated by an on-chip integrated heater. This innovative approach allows the tiny array of five sensors together with the integrated heater to occupy only approximately 50x200 μm2 and consume only 120 μW. The tiny and portable device can estimate the concentration of H2 and NH3 in a mixture with a root mean square error of 6.1 ppm and 13.3 ppm respectively, and it still works well after two months. The performance analysis of the double partial least squares regression used for concentration estimation allows also for feedbacking which sensors are the most sensitive to which gas, so that the electronic nose can be engineered for specific applications using the most suitable sensors. The size of the thermal electronic nose allows it to be integrated into portable and wearable devices, and its performance makes it suitable for any gas detection application. For example, a smartphone with an integrated sensor could carry out breath analysis and act as medical pre-screening, or be used to evaluate the freshness of agri-food products in a rapid and non-invasive way

Kommer tid kommer råd : Diskurser, resurser och roller i digitala språkhandledningssamtal

Språkverkstadsforskning är ett etablerat fält internationellt men ett litet fält i Sverige, trots att språkverkstäder finns vid i princip alla svenska högskolor och universitet. Föreliggande studie analyserar fyra inspelade digitala språkhandledningssamtal och åtta intervjuer med handledare och studenter genom medierad diskursanalys (Scollon och Scollon 2004; Blåsjö, Christensson och Hanell 2024). Med hjälp av teoretiska verktyg som diskursiva resurser, skrivdidaktiska diskurser (Ivanić 2004) och tidslinjer belyser uppsatsen hur idéer om akademisk text och skrivande konkret förmedlas och förhandlas i handlingssituationen.    Resultaten visar att såväl studentens text, bokningsformuläret, lärarens kommentarer och webbsidor fungerar som diskursiva resurser för att förmedla framförallt genre-, färdighets- och processdiskurs. Studenten tilldelas de något motstridiga rollerna som både elev och ”ägare” av texten medan handledaren fungerar främst som lärare och coach alternativt bollplank. Samtalens utformning, längd och placering i förhållande till den aktuella textens tidslinje antyder att det framförallt är den student som är metaspråkligt medveten och snabbt och självständigt kan omsätta råd till handling som har nytta av språkhandledningen. I ett längre tidsperspektiv kan andra studenter få nytta av handledningen då handledarna genom samtalen får en inblick i aktuella svårigheter för studenter, insikter som de tar med sig in i andra aktiviteter såsom föreläsningar om skrivande och fortbildning för universitetslärare