Restricted slowly growing digits for infinite iterated function systems

We prove that the Hausdorff dimension stays the same no matter how slowly the function φ grows. One of the consequences of our result is the recent work of Takahasi (2023), which only dealt with regular continued fraction expansions. We further extend our result to slowly growing products of (not necessarily consecutive) digits.</p

The Proteomic and RNA Cargo in Extracellular Vesicles associated with Amyotrophic Lateral Sclerosis

A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia.</p

Advancing Social Work Research in Australia: Experienced Researcher Perspectives

Abstract:While social work research in Australia is in reasonable shape, it requires a strong research culture promoting rigorous research to enhance its credibility and influence on social policy discourses. This study explored proposals to advance social work research, based on interviews with 20 experienced Australian social work researchers. Strategies identified include improving research culture and training, the development of research infrastructure to promote and stimulate research, and forming new partnerships both among researchers and between researchers and research end-users. Growing and strengthening the research foundations of the discipline is essential to its future relevance.</p

Exploring the identification, outcomes and experiences of women with a disability accessing public maternity services in Australia

A thesis submitted in total fulfilment of the requirements for the degree of Doctor of Philosophy to the Judith Lumley Centre, School of Nursing and Midwifery, La Trobe University, Victoria, Australia.</p

Popular Culture in the Classroom: Engaging With Ancient History Through Contemporary Media

Abstract:Many students are fascinated by Ancient Greece and Rome, but they May also find it difficult to relate to or understand these ancient cultures. Students commonly bring preconceived notions about the past to their studies, which May be based on their exposure to popular media such as films, television shows, video games, books and comics. Preconceptions often result in inaccurate perceptions of the past: perhaps they think of Greeks as perpetually surrounded by beautiful white statues, while Romans were never happy unless slaughtering animals in the arena. Preconceptions often reinforce stereotypes because the popular texts depicting ancient societies are mediated through a modern lens designed to appeal to twenty-first century audiences. As well as updating accepted fashions and cultural norms, antiquity May be sanitised to be made more familiar, for example, modernising conceptions of gender or race, centring nuclear family values, or downplaying slavery.</p

Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains

Scribble is a crucial adaptor protein that plays a pivotal role during establishment and control of cell polarity, impacting many physiological processes ranging from cell migration to immunity and organization of tissue architecture. Scribble harbours a leucine-rich repeat domain and four PDZ domains that mediate most of Scribble's interactions with other proteins. It has become increasingly clear that post-translational modifications substantially impact Scribble–ligand interactions, with phosphorylation being a major modulator of binding to Scribble. To better understand how Scribble PDZ domains direct cell polarity signalling and how phosphorylation impacts this process, we investigated human Scribble interactions with MCC (Mutated in Colorectal Cancer). We systematically evaluated the ability of all four individual Scribble PDZ domains to bind the PDZ-binding motif (PBM) of MCC as well as MCC phosphorylated at the −1 Ser position. We show that Scribble PDZ1 and PDZ3 are the major interactors with MCC, and that modifications to Ser at the −1 position in the MCC PBM only has a minor effect on binding to Scribble PDZ domains. We then examined the structural basis for these observations by determining the crystal structures of Scribble PDZ1 domain bound to both the unphosphorylated MCC PBM as well as phosphorylated MCC. Our structures indicated that phospho-Ser at the −1 position in MCC is not involved in major contacts with Scribble PDZ1, and in conjunction with our affinity measurements suggest that the impact of phosphorylation at the −1 position of MCC must extend beyond a simple modulation of the affinity for Scribble PDZ domains.</p

Structural insight into tanapoxvirus‐mediated inhibition of apoptosis

Premature programmed cell death or apoptosis of cells is a strategy utilized by multicellular organisms to counter microbial threats. Tanapoxvirus (TANV) is a large double-stranded DNA virus belonging to the poxviridae that causes mild monkeypox-like infections in humans and primates. TANV encodes for a putative apoptosis inhibitory protein 16L. We show that TANV16L is able to bind to a range of peptides spanning the BH3 motif of human proapoptotic Bcl-2 proteins and is able to counter growth arrest of yeast induced by human Bak and Bax. We then determined the crystal structures of TANV16L bound to three identified interactors, Bax, Bim and Puma BH3. TANV16L adopts a globular Bcl-2 fold comprising 7 α-helices and utilizes the canonical Bcl-2 binding groove to engage proapoptotic host cell Bcl-2 proteins. Unexpectedly, TANV16L is able to adopt both a monomeric and a domain-swapped dimeric topology where the α1 helix from one protomer is swapped into a neighbouring unit. Despite adopting two different oligomeric forms, the canonical ligand binding groove in TANV16L remains unchanged from monomer to domain-swapped dimer. Our results provide a structural and mechanistic basis for tanapoxvirus-mediated inhibition of host cell apoptosis and reveal the capacity of Bcl-2 proteins to adopt differential oligomeric states whilst maintaining the canonical ligand binding groove in an unchanged state. Database: Structural data are available in the Protein Data Bank (PDB) under the accession numbers 6TPQ, 6TQQ and 6TRR.</p

Beyond the New New Hollywood: The Effect of Digital Streaming Services on the Process of Allusionistic Interplay

A thesis submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy to the School of Humanities and Social Sciences, La Trobe University, Victoria, Australia.</p

Assessment of Inbreeding under Genomic Selection in Australian Dairy Cattle

A thesis submitted in total fulfillment of the requirements for the degree of Doctor of Philosophy [to the School of Applied Systems Biology], La Trobe University, Victoria, Australia.</p

Taxonomy and pollination of the sexually deceptive orchid Caladenia tensa

A thesis submitted in total fulfilment of the requirements for the degree of Master of Science to the School of Agriculture, Biomedicine and Environment, La Trobe University, Victoria, Australia.</p