Pre-Processing-based Fast Design of Multiple EM Structures with One Deep Neural Network

Deep learning plays a vital role in the design of electromagnetic (EM) structures. However, in current research, a single neural network typically supports only one structure design and requires a complex framework to accommodate multiple structure designs. This paper proposes using one neural-assist design for facilitating multiple EM structures. We employ two filling methods to control the vector length, an identification method to ensure accurate prediction results, and a random auxiliary vectors method to increase the data volume and reduce loss. Subsequently, we design a forward neural network (FNN) and an inverse neural network (INN) using the proposed method. The developed neural network is used to complete the dual-passband frequency selective surface (DP-FSS), space-time-coding digital metasurface element (STCDME), single/dual absorbing metasurface (SDAM), and dual-stopband frequency selective surface (DS-FSS) designs. The mean absolute error (MAE) loss values for the FNN/INN predictions and actual results for these four structures are 0.019/0.116, 0.035/0.602, 5.14/0.146, and 0.018/0.07, respectively. Finally, we design four structures with the well-training network, fabricate DP-FSS and DS-FSS, and measure them in an anechoic chamber. The measurement and simulation results are in good agreement. The proposed method significantly reduces the complexity of multiple EM structure designs, decreases the need for multiple neural networks, and simplifies the design framework, thereby contributing to the development of AI-assisted EM structures

Quality and impact of pharmacology digital simulation education on pre-registration healthcare students a systematic literature review

ObjectiveThis review aimed to assess the quality and nature of the literature related to digital simulation-based pharmacology education. Specifically, we sought to understand the influence of simulations on the knowledge, satisfaction, and confidence of pre-registration nurses and other healthcare students participating in such educational programs.DesignSystematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. This study was registered in the Prospective Register of Systematic Reviews (PROSPERO, reg no: CRD42023437570).Data sourcesPubMed, MEDLINE, APA PsycInfo, ProQuest, Web of Science, ScienceDirect, and CINHAL databases were searched.Review methodsThe review focused on the quantitative findings from the studies published from 2016 to 2023. Only the studies that assessed the impact of digital simulation-based pharmacology education on pre-registration healthcare students' knowledge, satisfaction, and confidence were selected for review. Data were synthesized using a narrative approach. The Mixed Methods Appraisal Tool (MMAT) was used to assess the quality of the included articles. This was followed by a narrative synthesis to consolidate the themes.ResultOut of 1587 articles,16 met the inclusion criteria. A wide variety of digital technologies have been utilised, such as virtual simulation, computer simulation (2D/3D), mixed reality, and augmented reality, with the majority using virtual simulation. All studies implemented single-user simulations. The themes emerging from the narrative synthesis suggest that a digital simulation-based pharmacology course is an effective tool for enhancing students' knowledge, confidence, and satisfaction in learning pharmacological concepts. Furthermore, simulation-based teaching with a blended approach was found to be beneficial. However, the integration of the polypharmacy concept and the intra and interprofessional approach to teaching and learning was not evident in these studies.ConclusionThis systematic literature review provides evidence of the potential of digital simulation-based education in pharmacology teaching among healthcare pre-registration students. In future studies, the integration of polypharmacy content with an intra and interprofessional teaching-learning approach is recommende

A single bout of vigorous intensity exercise enhances the efficacy of rituximab against human chronic lymphocytic leukaemia B-cells ex vivo

Chronic lymphocytic leukaemia (CLL) is characterised by the clonal proliferation and accumulation of mature B-cells and is often treated with rituximab, an anti-CD20 monoclonal antibody immunotherapy. Rituximab often fails to induce stringent disease eradication, due in part to failure of antibody-dependent cellular cytotoxicity (ADCC) which relies on natural killer (NK)-cells binding to rituximab-bound CD20 on B-cells. CLL cells are diffusely spread across lymphoid and other bodily tissues, and ADCC resistance in survival niches may be due to several factors including low NK-cell frequency and a suppressive stromal environment that promotes CLL cell survival. It is well established that exercise bouts induce a transient relocation of NK-cells and B-cells into peripheral blood, which could be harnessed to enhance the efficacy of rituximab in CLL by relocating both target and effector cells together with rituximab in blood. In this pilot study, n = 20 patients with treatment-naïve CLL completed a bout of cycling 15 % above anaerobic threshold for ∼ 30-minutes, with blood samples collected pre-, immediately post-, and 1-hour post-exercise. Flow cytometry revealed that exercise evoked a 254 % increase in effector (CD3−CD56+CD16+) NK-cells in blood, and a 67 % increase in CD5+CD19+CD20+ CLL cells in blood (all p < 0.005). NK-cells were isolated from blood samples pre-, and immediately post-exercise and incubated with primary isolated CLL cells with or without the presence of rituximab to determine specific lysis using a calcein-release assay. Rituximab-mediated cell lysis increased by 129 % following exercise (p < 0.001). Direct NK-cell lysis of CLL cells – independent of rituximab – was unchanged following exercise (p = 0.25). We conclude that exercise improved the efficacy of rituximab-mediated ADCC against autologous CLL cells ex vivo and propose that exercise should be explored as a means of enhancing clinical responses in patients receiving anti-CD20 immunotherapy

Mapping the landscape: surf therapy program delivery

Surf therapy is a structured intervention which utilizes surfing as a vehicle to achieve therapeutic benefit (International Surf Therapy Organization [ISTO], 2019). Surf therapy is presently delivered internationally within a diverse array of contexts and populations. Despite the publication of many internal evaluation studies, little research has examined themes common to the process of surf therapy across programs. The present study recruited a sample of ISTO-affiliated surf therapy programs (n = 33) to engage with an online survey, Mapping the Stoke, examining core aspects of surf therapy structure and process internationally. Findings indicated both similarities across current program delivery internationally, with examples of primary similarities including target age (adolescents and young adults) and population (mental health), recruitment (self-referral), and structure (group sessions), geographic delivery (major cities) and challenges (funding). Areas of greater diversity included support staff (roles/qualifications), therapeutic aims, measures (outcome) and therapeutic structures. The present study outlines concrete structures and processes which appear integral to the delivery of surf therapy across cultures

Depression and Health-Related Quality of Life Among Older Adults With Hearing Loss in the ACHIEVE Study

Hearing loss is associated with cognitive/physical health; less is known about mental health. We investigated associations between hearing loss severity, depression, and health-related quality of life among older adults with unaided hearing loss. Data (N = 948) were from the Aging and Cognitive Health Evaluation in Elders Study. Hearing was measured by pure-tone average (PTA), Quick Speech-in-Noise (QuickSIN) test, and the Hearing Handicap Inventory for the Elderly (HHIE-S). Outcomes were validated measures of depression and health-related quality of life. Associations were assessed by negative binomial regression. More severe hearing loss was associated with worse physical health–related quality of life (ratio: .98, 95% CI: .96, 1.00). Better QuickSIN was associated with higher mental health–related quality of life (1.01 [1.00, 1.02]). Worse HHIE-S was associated with depression (1.24 [1.16, 1.33]) and worse mental (.97 [.96, .98]) and physical (.95 [ .93, .96]) health–related quality of life. Further work will test effects of hearing intervention on mental health

Implementing responsible innovation: the role of the meso-level(s) between project and organisation

Much of academic discussion of responsible innovation (RI) has focused on RI integration into research projects. In addition, significant attention has also been paid to RI structures and policies at the research policy and institutional level. This article reports experiences of RI implementation with a focus on the intermediate i.e. meso-level. The research described here included a series of interviews that aimed to clarify researchers' perspectives on RI as well as barriers to and benefits of RI implementation. Two cases of engagement with research projects, with the aim of promoting RI, were undertaken. The analysis of the data demonstrates the crucial contribution that the meso-level of a research programme can make in interpreting, implementing and perpetuating RI across related activities. The article provides strong evidence that the scholarly debate surrounding RI should pay more explicit attention to this meso-level, ultimately strengthening RI theory and practice

Detention of children and adolescents under mental health legislation: a scoping review of prevalence, risk factors, and legal frameworks

Background: For individuals with severe mental illness, involuntary assessment and/or treatment (hereafter detention) can be a necessary intervention to support recovery and may even be lifesaving. Despite this, little is known about how often these interventions are used for children and adolescents. Methods: This global scoping review set out to: (1) map the current evidence around mental health detentions of children and adolescents (< 18 years); (2) identify the clinical, sociodemographic, and behavioural factors associated with detention; and (3) document the views of professionals and young people on the implementation of mental health legislation. Results: After searching databases of peer-reviewed literature and citation chaining, 42 articles from 15 jurisdictions were included. About one fifth of psychiatric admissions in national register data were detentions, however trends were only available for a few high-income Western countries. The circumstances justifying detention and the criteria authorising detention varied between studies, with a mix of clinical factors and observed behaviours reported as the reason(s) warranting/precipitating a detention. Particular groups were more likely to experience detention, such as children and adolescents from minority ethnic communities and those with a documented history of abuse. There was a notable absence of qualitative research exploring the views of professionals or children and adolescents on detention. Conclusion: Further research is needed to explore the impact of detention on those aged < 18 years, including national register-based studies and qualitative studies. This is particularly relevant in nations currently undergoing legislative reform

Gender Balance on State Boards in Ireland: To the Forefront of Progress or Concealing the Status Quo?

In this article, we examine female appointments to government-owned corporations, called State Sponsored Boards (SSBs), in Ireland over a twenty-eight-year period, to analyze the extent to which gender parity has been achieved using voluntary gender targets. Using data from thirty-four SSBs, we found that overall figures relating to the achievement of gender parity on SSBs are masking the reality of female representation on these boards. We have demonstrated that the high concentration of females on particular boards is increasing the overall average gender representation figures, and as a result, a high proportion of boards are not meeting their gender targets. This research provides evidence of the importance of taking a more nuanced approach to examining gender diversity on boards as a whole

Football viewing centres in an African megacity: viewers’ characteristics and operational dynamics

This study examines viewers’ characteristics and operational dynamics of football viewing centres (FVCs) in Agege, Lagos Megacity, Nigeria. It anchors on the “theory of happiness” and the microeconomic vitality of FVCs using a mixed-methods approach. The results of the descriptive and inferential statistics revealed that most viewers can afford subscriptions for digital TV in their homes, yet patronize the FVCs. Factors attributed to patronage are happiness, excitement, and other social opportunities, with some perspectives of leisure and microeconomic vitality benefits. Finally, the study suggests a new policy direction to mitigate the negative effects of unplanned areas resulting in the proliferation of FVCs

Suicide prevention: Introducing the Lothian Safekeeping Plan © for parents as a clinical innovation for use alongside safety plans for children and young people

Topic: Internationally, preventing suicide in children and young people is a priority and there are a range of preventative approaches available for health professionals to use, including brief interventions. Safety planning is one such brief intervention. Safety plans have long been recommended for use with young people who are suicidal but, these were initially developed for adults. A recent scoping review revealed safety plans need to be tailored to children and young people. This review also identified an important practice gap, that parents also require plans supporting them to keep their child safe. Purpose: This paper highlights how a Scottish clinical child and adolescent mental health setting in the UK's National Health Service developed and implemented evidence‐based safety plans for suicidality–the Lothian Safety Plan for young people and the Lothian Safekeeping Plan for parents. This paper outlines both plans and gives recommendations for their use by healthcare professionals. The parental Lothian Safekeeping Plan is discussed in more depth as this is a novel intervention. Conclusion: The Lothian Safekeeping Plan is a clinically led evidence‐based practice innovation. It is a specific suicide prevention plan for use by parents as an additional, complementary, and enhanced resource to the Lothian Safety Plan for young people. It is recommended that healthcare professionals also use a parental safety plan when supporting young people presenting with suicidal crisis. Further research is needed to evaluate the impact of these plans