A critical voice on the Hajj by a Sumatran pilgrim from the early twentieth century

This paper examines a late 19th-century brochure entitled ‘Perdjalanan ke-‘Tanah-Tjoetji’ (A Pilgrimage to the ‘Holy Land’) written by Dja Edar Moeda, a Dutch-educated native teacher and a pioneer journalist and vernacular press entrepreneur in Sumatra. The text offers a critical perspective on the Hajj, differing from the majority of this corpus, which tends to show religious enthusiasm and saintly connotations. This paper demonstrates that the ‘deviant’ voice on the Hajj in the Brochure reflects the author’s concerns. As a native intellectual and religious modernist with a Western-secular education, he worries about the fate of his fellow native pilgrims, who are often victimised by rampant fraudulent practices in the organisation of the Hajj due to their illiteracy, map illiteracy, innocence, naivety and tendency to be submissive in their religious practice. In this respect, the Brochure indirectly criticises the Dutch East Indies colonial authority’s deficiencies in organising the pilgrimage and protecting the pilgrims as its colonial subjects.Asian Studie

Complex karyotype but not other cytogenetic abnormalities is associated with worse posttransplant survival of patients with nucleophosmin 1-mutated acute myeloid leukemia: A study from the European Society for Blood and Marrow Transplantation Acute Leukemia Working Party

n the 2022 European LeukemiaNet classification, patients with nucleophosmin 1 (NPM1)-mutated acute myeloid leukemia (AML) were classified in the adverse-risk category in the presence of high-risk cytogenetics (CG). Nonetheless, the impact of various CG aberrations on posttransplant outcomes remains to be unraveled. This registry study analyzed adult patients with NPM1-mutated de novo AML who underwent their first allogeneic hematopoietic cell transplantation in the first complete remission from 2005 to 2021. A total of 3275 patients were identified, 2782 had normal karyotype, 493 had chromosomal aberrations including 160 with adverse-risk CG, 72 patients had complex karyotype (CK), and 66 monosomal karyotype (MK). Overall, 2377 (73%) patients had FLT3-ITD. On univariate analysis, only FLT3-ITD, minimal/measurable residual disease (MRD) positivity and CK, but not abnormal CG, affected posttransplant outcomes. On multivariable analysis, CK was associated with lower overall survival (OS) (hazard ratio [HR] 1.72, p = .009). In the subgroup of 493 patients with aberrant CG, the 2-year leukemia-free survival (LFS) and OS were around 61% and 68%, respectively. On multivariable analysis for this subgroup, CK and MRD positivity were associated with increased risk of relapse (HR 1.7, p = .025; and 1.99, p = .003 respectively) and worse LFS (HR 1.62, p = .018; and 1.64, p = .011 respectively) while FLT3-ITD, MK, or other CG abnormalities had no significant effect. Importantly, CK negatively affected OS (HR 1.91, p = .002). In the first complete remission transplant setting, CK was found as the only cytogenetic risk factor for worse outcomes in NPM1-mutated AML. Nevertheless, even for this subgroup, a significant proportion of patients can achieve long-term posttransplant survival.Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Antigen-specific Fab profiling achieves molecular-resolution analysis of human autoantibody repertoires in rheumatoid arthritis

The presence of autoantibodies is a defining feature of many autoimmune diseases. The number of unique autoantibody clones is conceivably limited by immune tolerance mechanisms, but unknown due to limitations of the currently applied technologies. Here, we introduce an autoantigen-specific liquid chromatography-mass spectrometry-based IgG1 Fab profiling approach using the anti-citrullinated protein antibody (ACPA) repertoire in rheumatoid arthritis (RA) as an example. We show that each patient harbors a unique and diverse ACPA IgG1 repertoire dominated by only a few antibody clones. In contrast to the total plasma IgG1 antibody repertoire, the ACPA IgG1 sub-repertoire is characterised by an expansion of antibodies that harbor one, two or even more Fab glycans, and different glycovariants of the same clone can be detected. Together, our data indicate that the autoantibody response in a prominent human autoimmune disease is complex, unique to each patient and dominated by a relatively low number of clones.</p

Promovendireeks #13: Is het Amerikaanse Hooggerechtshof stuk? Een onderzoek naar interne verbeteringen ten behoeve van een eerlijk proces en een eerlijke rechter

The Legitimacy and Effectiveness of Law & Governance in a World of Multilevel Jurisdiction

Defining key concepts for mental state attribution

Advanced Behavioural Research Method

Recommendations for a better understanding of sex and gender in the neuroscience of mental health

Pathways through AdolescenceHealth and self-regulatio

Aggregate formation and antibody stability in infusion bags: the impact of manual and robotic compounding of monoclonal antibodies

Pharmacolog

‘Every entry should be the last’: archiving the war and producing implicated publics in Yevgenia Belorusets’: a wartime diary (2022)

Modern and Contemporary Studie

Challenging the dogma: red blood cell-directed autoimmunity as risk factor for red blood cell alloimmunisation after blood transfusion

Red blood cell autoimmunity and alloimmunity are potentially linked. Quantification of this association can tailor extensively matched red blood cell transfusions in patients with autoimmunity. Using an incident new-user cohort comprising 47 285 previously non-transfused, non-alloimmunised patients, we compared transfusion-induced red blood cell alloimmunisation incidences in direct antiglobulin test (DAT)-positive and control patients. Additionally, we performed case–control analyses to handle potential confounding by clinical immunomodulators. Among (IgG and/or C3d) DAT-positive patients (N = 380), cumulative red blood cell alloimmunisation incidences after 10 units transfused reached 4.5% (95% confidence interval [CI] 2.5–8.2) versus 4.2% (CI 3.9–4.5, p = 0.88) in controls. In case–control analyses, alloimmunisation relative risks among DAT-positive patients increased to 1.7 (CI 1.1–2.8). Additional adjustments for pre-DAT transfusion exposure or the extent of Rh/K mismatching did not impact results. In conclusion, while patients with DAT positivity show an intrinsically increased alloimmune red blood cell response, their absolute risk is comparable to control patients due to counteracting co-existing immunosuppressive conditions. Consequently, isolated DAT positivity in patients lacking overt haemolysis or complicated alloantibody testing does not seem to warrant extended matching strategies. Immunobiology of allogeneic stem cell transplantation and immunotherapy of hematological disease

Object analysis and species identification of an Asháninka hood from the Rio Ene valley, Peru

NWOPlant science