Lysogenic control of Bacillus subtilis morphology and fitness by Spbetavirus phi3T

Microbial Biotechnolog

Neural correlates of loudness coding in two types of cochlear implants-A model study

Many speech coding strategies have been developed over the years, but comparing them has been convoluted due to the difficulty in disentangling brand-specific and patient-specific factors from strategy-specific factors that contribute to speech understanding. Here, we present a comparison with a 'virtual' patient, by comparing two strategies from two different manufacturers, Advanced Combination Encoder (ACE) versus HiResolution Fidelity 120 (F120), running on two different implant systems in a computational model with the same anatomy and neural properties. We fitted both strategies to an expected T-level and C- or M-level based on the spike rate for each electrode contact's allocated frequency (center electrode frequency) of the respective array. This paper highlights neural and electrical differences due to brand-specific characteristics such as pulse rate/channel, recruitment of adjacent electrodes, and presence of subthreshold pulses or interphase gaps. These differences lead to considerably different recruitment patterns of nerve fibers, while achieving the same total spike rates, i.e., loudness percepts. Also, loudness growth curves differ significantly between brands. The model is able to demonstrate considerable electrical and neural differences in the way loudness growth is achieved in CIs from different manufacturers.Disorders of the head and nec

Conrad in the anthropocene

Modern and Contemporary Studie

Life after loss: long-term impact of parental death during childhood

The death of a parent during childhood is an impactful event, with large implications throughout the child’s life. The current dissertation aimed to provide insight into the long-term impact after the death of a parent during childhood (CPD) and into potential risk and protective factors. We investigated this by using questionnaires and semi-structured interviews. Participants were adults who lost one of their biological parents during childhood (between 4-17 years) and two comparison groups of adults who did not lose their parent (during childhood).This dissertation shows how adults who experienced CPD reported similar levels regarding most health, relational, and parenting outcomes as adults who did not experience CPD. However, the loss may be related to anxious feelings of losing another important person in one’s life. Additionally, interviews with participants showed how specific days/moments, certain non-sensitive responses, or a lack of attention or support may trigger or intensify grief. Findings show how children’s coping and adaptation after the loss may be either complicated or facilitated by factors related to the family and social environment. Psychoeducation on the impact of CPD may help to provide tailored support for children who lost their parent.The research described in this dissertation was financially supported by the Leiden University Fund (LUF) through a grant awarded to prof.dr. L. R. A. Alink (grant number W18602-5-103), and by Leiden University.Education and Child Studie

An egg is always an adventure: anthropogenic impacts on Culex pipiens population dynamics

Anthropogenic change is reshaping ecological systems, raising concerns about increasing transmission of infectious diseases. Among these, mosquito-borne diseases may be particularly sensitive to environmental change, as their transmission depends on vector populations. Understanding how changes in the interplay between the environment, vector populations, and animal and human hosts relate to the increasing incidence and spread of pathogens, is crucial in anticipating and mitigating outbreaks. This thesis investigates how anthropogenic pressures – like climate change, water management and land use – affect the population dynamics of the disease vector Culex pipiens, whilst demonstrating the necessity of considering ecological complexity and realism in One Health studies.NWONWA.1160.1S.210Environmental Biolog

Raymond Corbey: a philosophical thorn in the side of archaeologists and much more

Who knew that “Sitting on the fence” could lead to such a versatile and inspiring academic biography? Raymond Corbey has moved across so many different areas of research that few of his colleagues realise the enormous scope and productivity of this epistemologist’s life. A retrospective and a celebration are thus, we think, in order.World Archaeolog

Homo ludens: Huizinga's spel met het Sanskriet

Asian Studie

Deciphering the Ubiquitin CODE by chemical tools

The scope of this PhD dissertation encompasses the study of Ub CODE signaling and druggability of E3 ligases by in-house developed chemical tools, aiming at its deciphering and modulation. The research presented in this thesis was performed at the Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. The research was supported by the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 765445.LUMC / Geneeskund

Exploring new horizons: challenges and opportunities for ehealth in geriatric rehabilitation

eHealth holds potential to improving rehabilitation outcomes for older adults receiving geriatric rehabilitation. Blended and simple eHealth interventions are the most promising and feasible. Despite these potentials, the adoption of eHealth in geriatric rehabilitation is still limited. Key barriers need to be overcome, such as the lack of usability outcomes, the lack of an organization-wide implementation strategy and the urgent need for healthcare professionals for reliable information on how to effectively identify, use and evaluate eHealth. Additionally, wearable sensors have proven to be capable of quantifying physical activity, sedentary behaviour and the patterns of sedentary in older adults during and after geriatric rehabilitation. Notably, this population engages in very low levels of physical activity and spends the majority of their waking hours in sedentary behaviour. Finally, The use of wearable sensors show potential in improving the prediction of functional recovery at discharge.LUMC / Geneeskund

Het recht op informatie in bestuursrechtelijke procedures

The Legitimacy and Effectiveness of Law & Governance in a World of Multilevel Jurisdiction