Decomposing the genetic background of chronic back pain.

peer reviewedChronic back pain (CBP) is a disabling condition with a lifetime prevalence of 40% and a substantial socioeconomic burden. Because of the high heterogeneity of CBP, subphenotyping may help to improve prediction and support personalized treatment of CBP. To investigate CBP subphenotypes, we decomposed its genetic background into a shared one common to other chronic pain conditions (back, neck, hip, knee, stomach, and head pain) and unshared genetic background specific to CBP. We identified and replicated 18 genes with shared impact across different chronic pain conditions and two genes that were specific for CBP. Among people with CBP, we demonstrated that polygenic risk scores accounting for the shared and unshared genetic backgrounds of CBP may underpin different CBP subphenotypes. These subphenotypes are characterized by varying genetic predisposition to diverse medical conditions and interventions such as diabetes mellitus, myocardial infarction, diagnostic endoscopic procedures, and surgery involving muscles, bones, and joints

The multiverse of volatolomic: apply PCA or/and PLSDA to outperform our data set

Volatolomics, the comprehensive analysis of volatile organic compounds (VOCs), has emerged as a powerful approach in many fields ranging from clinical diagnostics and food safety to environmental monitoring. Chromatographic techniques such as gas chromatography–mass spectrometry (GC-MS) and two-dimensional gas chromatography (GC×GC) generate increasingly complex datasets that require advanced statistical tools for interpretation. Among these, Principal Component Analysis (PCA) and Partial Least Squares Discriminant Analysis (PLS-DA) are two multivariate methods often employed to enhance important information from these datasets. This presentation provides a comparative overview of PCA and PLS-DA as applied to volatolomic data, focusing on their respective strengths, limitations, and practical applications. Real dataset obtained in the field of forensic analyses and pest management will illustrate how PCA, an unsupervised method, is effective for initial data exploration, pattern recognition, and outlier detection, while PLS-DA, a supervised method, enables predictive modeling and identification of key VOC markers linked to specific classes. We demonstrate how these tools can be used complementarily, offering a practical workflow for exploratory analysis, classification, and identification of key volatile markers. This comparative analysis underscores the importance of choosing the appropriate multivariate technique based on study objectives. When combined, PCA and PLS-DA provide a robust strategy for the analysis and interpretation of high-dimensional chromatographic volatolomic data. Best practices in model validation and result interpretation will also be discussed, ensuring reproducibility and reliability across a broad range of separation science applications

Science et confort à la fin du XIXe siècle : le chauffage et la ventilation des Instituts Trasenster, à l’Université de Liège (1880-1889)

Cette contribution vise à appréhender le confort dans les instituts scientifiques en Europe durant le dernier quart du XIXe siècle. Elle s'intéresse aux techniques spéciales, non seulement sous l’angle technologique, mais également au sein de l’histoire culturelle et sociale, s’inscrivant dans des thématiques développées notamment par Emmanuelle Gallo. La fin du XIXe siècle vit le perfectionnement des nouveaux équipements développés en Europe dès le tournant des années 1800, dans une recherche de confort, de propreté et d’ordre, devenus synonymes de progrès social et intellectuel. En Belgique, les instituts universitaires, se voulant performants et modernes, bénéficièrent entre-autres de ces systèmes techniques en pleine évolution. Ces édifices, émergeant à partir des années 1880, furent notamment réalisés à Bruxelles grâce au soutien financier de mécènes, ainsi qu’à Gand et à Liège grâce à celui des autorités nationales et locales. Leur construction s’inscrivait plus largement dans une dynamique de transformation majeure des établissements scientifiques en Europe, initiée par les universités allemandes. Dans ce contexte, l’observation du confort offert aux professeurs et aux étudiants révèle une facette du rôle (moteur ou entrave) que joua l’architecture durant une importante période d’essor scientifique. Cette contribution se focalise sur la ventilation et le chauffage des Instituts Trasenster construits à Liège, entre 1880 et 1889. Ces installations sont plutôt bien documentées dans les fonds d’archives ciblés (appartenant notamment au Service des Ponts et Chaussées), dévoilant la collaboration d’un éventail d’acteurs (personnel universitaire, constructeurs, entrepreneurs, ingénieurs, ministres) et mettant en lumière certains processus décisionnels et la diffusion de savoirs techniques au sein du Ministère des Travaux publics et des universités. Cette approche s'inscrit dans un projet de recherche doctoral, porté par l'Université de Liège et l'Universiteit Antwerpen, ayant pour objet d’étude la conception architecturale et technique, le chantier de construction et la réception de cet ensemble architectural exceptionnel

Translating Musical Theatre Songs, or the Importance of Being Faithfully Flexible and Flexibly Faithful

peer reviewedBien qu'ayant reçu davantage d'attention depuis le début des années 2000, la traduction de textes destinés à être chantés reste un domaine peu étudié en traductologie. La traduction de chansons de comédie musicale ne fait pas exception à la règle puisqu'elle est souvent laissée de côté, contrairement à la traduction de chants d'opéra ou de chansons de variété. De ce constat est né notre souhait de créer ce que nous appelons le New Pentathlon Tool, un outil tant analytique que d'aide à la traduction qui s'inspire du Pentathlon Principle de Peter Low et qui s'articule autour des notions de fidélité et de flexibilité, deux notions étroitement liées qui, en traduction de chansons, sont loin de s’exclure mutuellement.The translation of singable texts remains a field that has received little scientific attention, despite an increase in the number of papers published on the subject of song translation since the early 21st century. The translation of musical theatre songs is no exception to the trend, as it is often overlooked by scholars in comparison to that of operatic or pop songs. This has led us to develop what we call the New Pentathlon Tool – a tool for translation and quality assessment – based on Peter Low’s Pentathlon Principle and centred on fidelity and flexibility, two closely related concepts which are by no means mutually exclusive in the field of song translation

A stochastic Petri net model of jamming attacks on remote-controlled switches during service restoration

peer reviewedCyber-attackers can take the advantage of accessibility to field devices to disrupt distribution system (DS) operation. Among field devices, remote-controlled switches (RCSs) play a key role in the fault detection, isolation, and restoration (FDIR) process. Jamming attacks do not require intrusion into the cyber-network of DSs. Thus, RCSs can be easily targeted by jammers. To address this concern, this paper proposes a novel model for simulating jamming attacks against RCSs during an FDIR process. To this end, a novel stochastic Petri net model is proposed that includes two sub-models: jamming-strategy model and trip-issuing model. Using this model, the probability of successful jamming attacks on a target RCS is calculated. In the hypothesized scenario, the attackers create man-made faults on some distribution lines, prompting the distribution system operator (DSO) to initiate an FDIR process. At the same time, they start launching jamming attacks on RCSs. This model can be used by the DSO for performing risk assessment analysis. To show how the jamming attacks could impact DSs, a distribution feeder is studied under the jamming attacks during the FDIR process. Then, the probability of successful jamming attacks, load restoration times, and expected energy not served (EENS) are analyzed in different situations.CYPRES

Impact of entomopathogenic fungi on soil non-target species

The ban on chemical pesticides for insect pest control has intensified the search for alternative strategies, including the use of biocidal microorganisms such as entomopathogenic fungi (EPF). These agents are promising tools for sustainable pest management, yet their ecological safety, particularly sublethal effects on non-target organisms, remains an area requiring deeper exploration. This study assessed the safety of a new EPF formulation targeting wireworms, a major soil-dwelling pest, by evaluating lethal and sublethal impacts on three non-target species: the common black ant (Lasius niger), the ground beetle (Pterostichus melanarius), and the earthworm (Eisenia fetida). After exposing ant colonies for one-hour or 24-hour to the formulation, we found no impact on ants’ survival and foraging behavior. Ground beetles’ survival was monitored over 21 days of continuous exposure and, although no significant mortality was observed, a behavioral assay revealed an increased biting frequency in the presence of EPF formulation, possibly indicative of altered stress or foraging responses. E. fetida, survival was evaluated over 28 days, and morbidity and behavior were assessed after exposure. While EPF did not impact survival, locomotor activity, or reproductive capacity, earthworms exhibited reduced weight gain and increased foraging behavior. These findings demonstrate that while the EPF formulation targeting wireworms does not exhibit biocidal effects on these non-target species, subtle behavioral and physiological changes may occur, potentially impacting ecosystem functions such as predation, decomposition, and soil health. This study highlights a persistent gap in understanding their ecological implications and calls for the integration of these endpoints into routine risk assessment protocols for biocontrol agents

Adolescents with Cystic Fibrosis Expressing their Possible Selves through Photovoice: A Longitudinal Interpretative Phenomenological Analysis to Prepare a Peer Support Intervention for Healthcare Transition

peer reviewe

Restauration de l'Hôtel de Ville de Malmedu : un patrimoine exceptionnel

Under Prussian rule, Fritz Maiter (Malmedy, 1881 - Malmedy, 1954) designed the town hall, the Lang and Steisel villas and most of the single-family homes on Rue Jules Steinbach. After the Treaty of Versailles, this «Bauwerkmeister» became the architect for the town of Malmedy (CURIEN & NELLES, 2022).Sous le régime prussien, les plans de l’Hôtel de Ville, des villas Lang et Steisel, ainsi que la plupart des maisons unifamiliales de la rue Jules Steinbach, ont été réalisés par Fritz Maiter (Malmedy, 1881 – Malmedy, 1954). Après le Traité de Versailles, ce «Bauwerkmeister» devint l’architecte de la Ville de Malmedy (CURIEN & NELLES, 2022).Während der preußischen Herrschaft wurden die Pläne für das Rathaus, die Villen Lang und Steisel sowie die meisten Einfamilienhäuser in der Rue Jules Steinbach von Fritz Maiter (Malmedy, 1881 - Malmedy, 1954) entworfen. Nach dem Versailler Vertrag wurde dieser „Bauwerkmeister“ zum Architekten der Stadt Malmedy (Curien & Nelles, 2022). Jules Steinbach schenkte der Gemeinde Malmedy am 28. September 1901 das Rathaus, ein außergewöhnliches ErbeOnder Pruisisch bewind ontwierp Fritz Maiter (Malmedy, 1881 - Malmedy, 1954) het stadhuis, de villa's Lang en Steisel en de meeste eengezinswoningen in de Rue Jules Steinbach. Na het Verdrag van Versailles werd deze “Bauwerkmeister” de architect van de stad Malmedy (Curien & Nelles, 2022). Op 28 september 1901 schonk Jules Steinbach het stadhuis aan de gemeente Malmedy, een uitzonderlijke erfgoedsite.Sotto la dominazione prussiana, Fritz Maiter (Malmedy, 1881 - Malmedy, 1954) progettò il municipio, le ville Lang e Steisel e la maggior parte delle case unifamiliari di Rue Jules Steinbach. Dopo il Trattato di Versailles, questo “Bauwerkmeister” divenne l'architetto della città di Malmedy (Curien & Nelles, 2022). Il 28 settembre 1901, Jules Steinbach donò al comune di Malmedy il municipio, un patrimonio eccezionale.Bajo el dominio prusiano, Fritz Maiter (Malmedy, 1881 - Malmedy, 1954) diseñó el ayuntamiento, las villas Lang y Steisel y la mayoría de las viviendas unifamiliares de la calle Jules Steinbach. Tras el Tratado de Versalles, este «Bauwerkmeister» se convirtió en el arquitecto de la ciudad de Malmedy (Curien & Nelles, 2022). Bajo el dominio prusiano, Fritz Maiter (Malmedy, 1881 - Malmedy, 1954) diseñó el ayuntamiento, las villas Lang y Steisel y la mayoría de las viviendas unifamiliares de la calle Jules Steinbach. Tras el Tratado de Versalles, este «Bauwerkmeister» se convirtió en el arquitecto de la ciudad de Malmedy (Curien & Nelles, 2022). El 28 de septiembre de 1901, Jules Steinbach donó el Ayuntamiento al municipio de Malmedy, patrimonio excepcionalプロイセンの支配下、フリッツ・マイテル（マルメディ、1881年～マルメディ、1954年）は、市庁舎、ラングとシュタイゼルの別荘、ジュール・シュタインバッハ通りの一戸建てのほとんどを設計した。ヴェルサイユ条約後、この「バウヴェルクマイスター」はマルメディの町の建築家となった（Curien & Nelles,في ظل الحكم البروسي، تم تنفيذ مخططات مبنى البلدية وفيلات لانغ وستايزل، بالإضافة إلى معظم المنازل الفردية في شارع جول شتاينباخ، من قبل فريتز مايتر (مالميدي، 1881 - مالميدي، 1954). بعد معاهدة فرساي، أصبح هذا ”الباووركمايستر“ مهندس11. Sustainable cities and communitie

Recensione a E. Orlando, G. Ortalli (a c. di), Dimensioni istituzionali del Commonwealth veneziano (secoli XIV-XVII) (Venezia: Istituto Veneto di Scienze Lettere e Arti, 2024)

peer reviewedDiplomatiCon: A Connected History of Medieval Mediterranean Diplomac

Comments on: Impact of direct access on the quality of primary care musculoskeletal physiotherapy: a scoping review from a patient, provider, and societal perspective

editorial reviewe