InTouch Week of March 25, 2024

35th Annual Graduate Student Research Forum Showcases Groundbreaking Research NYMC and Regeneron Debut Neighborhood Science Seminar Series Orthopedics Research Fellowship Yields Prolific Results for SOM Student LCME Elements of the Week Tell Us What You Think Alumni Spotlight: SLP Alumna Opens Local Private Practice in Honor of Late Sisterhttps://touroscholar.touro.edu/in_touch/1320/thumbnail.jp

Management of an Undetectable Diverticular Bleed: A Case Report and Literature Review

Diverticular bleeding is the most common cause of lower gastrointestinal bleeding and accounts for 20.8%-41.6% of cases in the Western world. Management involves initial resuscitation followed by diagnostic assessment. Colonoscopy is the investigation of choice as it localizes the bleed and has the potential to effectively deliver therapeutic interventions. Other diagnostic modalities include flexible sigmoidoscopy, a tagged red blood cell scan, or angiography. In cases where the bleeding source cannot be identified, intraoperative enteroscopy has emerged as a valuable tool for investigating obscure gastroenterology bleeds in specific patients. In this case report, we describe the management of a 77-year-old male with recently diagnosed pan-colonic diverticulosis who presented with multiple episodes of rectal bleeding and syncope. Due to his declining hemodynamic status and failed endoscopy and embolization, he was taken to surgery for a colectomy. Intraoperative colonoscopy was utilized to facilitate accurate identification of the pathology, assessment of anastomotic patency, and detection of surgical complications. This case report attempts to portray how the incorporation of endo-videoscopy into surgical planning has the potential to enhance patient outcomes and represent a significant advancement in the field of minimally invasive surgery

Treatment of Medication-Related Osteonecrosis of the Jaw: Controversies in Causality and Therapy

Medication-related osteonecrosis of the jaw (MRONJ) is a most interesting, complex and elusive condition seen by the oral health care provider. It is plagued by controversy and although a wealth of research has created clinical treatment databases, there is no gold standard algorithm to be applied in a universal fashion. The purpose of this article is to explore several controversies associated with the etiology(s), staging, treatments, and long-term resolution of MRONJ in patients who are treated by the oral health care provider. Controversies for optimizing prevention, and disease control will also be discussed from an interdisciplinary perspective

Expanding the Differential Diagnosis of the Painful Nail: A Case of an Onychopapilloma with Neuroma

INTRODUCTION: Onychopapilloma most commonly presents as longitudinal erythronychia, but diagnosis may be challenging in some cases due to varied clinical presentations. Most patients with onychopapillomas do not report associated pain but instead more commonly report functional interference. CASE REPORT: We present a case of a 74-year-old female with a 5-year history of splitting and lifting of the right thumbnail, accompanied by nail sensitivity and intermittent painful throbbing. Clinical examination was significant for a less than 1 mm red line with distal onycholysis. Love\u27s test and a cold test performed with ice pack were negative. X-ray of the right thumb was negative for erosion or exostosis. Nail biopsy was performed, and dermatopathology was consistent with onychopapilloma with a concomitant traumatic neuroma. CONCLUSION: We report a case of onychopapilloma with a concomitant traumatic neuroma. Subungual neuromas are extremely rare and have not previously been associated with onychopapilloma. Our case supports the expansion of the differential diagnosis for a painful nail and demonstrates the importance of diagnostic confirmation with biopsy and histopathology

Mycophenolate Mofetil versus Prednisone for Induction Therapy in Steroid-Sensitive Idiopathic Nephrotic Syndrome in Children: An Observational Study

RATIONALE & OBJECTIVE: High-dose steroids are recommended for the induction of idiopathic nephrotic syndrome. The aim of this study was to compare standard induction therapy with Mycophenolate Mofetil (MMF). We hypothesized that MMF could be noninferior to steroids in maintaining steroid-induced remission. The second aim was to reduce steroid-induced side effects. STUDY DESIGN: This was an observational study. SETTING & POPULATION: Patients 2-11 years with first episode of nephrotic syndrome who entered remission within 2 weeks of standard steroid treatment were eligible for enrollment. Patients in the experimental group completed 12-week induction with MMF, whereas the control group continued a standard 12-week steroid protocol. EXPOSURES: MMF and prednisolone were used in the study. OUTCOMES: The primary study outcomes were relapse rate and relapse-free interval during a 52-week follow-up. ANALYTICAL APPROACH: Descriptive statistics were used for analysis. RESULTS: Ten of 41 eligible patients consented to participate in the MMF group and 8 completed the study. The control group included 31 patients, with 23 patients who completed 52 weeks follow-up. During the induction phase, 3 out of 10 patients (30%) in the MMF group and 1 out of 31 (3%) in the control group ( = 0.04) developed relapse. During the 52 weeks follow-up period, 7 out of 10 patients (70%) in the MMF group and 19 out of 31 (61%) in the control group developed relapse ( = 0.72). The median relapse-free interval was 11 and 19 weeks in MMF and control groups, respectively ( = 0.60). No serious side effects were recorded in either group. LIMITATIONS: The limitations of the study were low patient numbers receiving MMF and single-center design. CONCLUSIONS: Our small cohort of patients treated with MMF reported a higher relapse rate during the induction phase. However, by 12 months of follow-up the relapse rate and relapse-free intervals were similar between both groups. All patients tolerated MMF without significant side effects, and those who relapsed remained steroid-sensitive