The Narratives of Cicero's Epistulae ad Quintum Fratrem: career, republic and the Epistulae ad Atticum

The narrative and design of Cicero's overlooked collection of letters to his brother Quintus (henceforth, QFr.) demand investigation. Within each book, the constituent letters delineate the trajectory of Cicero's life, transitioning from his political prominence to his increasing irrelevance. This narrative unfolds not only within the micro-narratives of individual books but also across the macro-narrative of the entire collection. Containing only letters from Cicero to Quintus dated between 60/59–54 and featuring a notable resemblance to the Epistulae ad Atticum (henceforth, Att.) Books 2–4, QFr., it can be argued, functions as both a ‘microcosm’ of Att. and its supplement. This article addresses these issues and argues that QFr. deserves a place alongside the ‘major’ Ciceronian collections

Personalised Health Behaviour Support Programme in Adults With Post-COVID Syndrome: A Randomised, Controlled Pilot Feasibility Trial

BackgroundWe investigated whether a novel 8-week personalised health behaviour support programme, focusing on the stability of symptoms and strategies to improve activities of daily living, was feasible and acceptable in adults with post-COVID syndrome.MethodsIn this randomised, controlled, pilot feasibility trial, 32 adults with post-COVID syndrome (continued symptoms for ≥ 12 weeks) were randomised 1:1 to receive personalised health behaviour support (self-reported physical activity and symptom diaries, plus seven one-to-one remotely delivered personalised self-management support sessions), once weekly for 8-weeks, or usual care (referral to online ‘your COVID-19 recovery’ programme). The primary outcome was the feasibility of recruiting and randomising adults with post-COVID syndrome. The secondary outcomes were to assess the acceptability and safety of the intervention and various outcome measures.ResultsOf the 48 adults who expressed interest in the study, 32 (67%) were eligible and completed the baseline assessment. All 32 adults were willing to be randomised to either the personalised health behaviour support programme (n = 17) or usual care (n = 15) and 27 (age: 45 ± 12 years) adults completed follow-up at 9 weeks. The intervention was deemed feasible, with high adherence (92% and 94% completion rates for the physical activity and symptom diaries, respectively) and excellent acceptability rates (94% ‘liked the intervention a lot’). The intervention was deemed safe, with no symptom exacerbations reported.ConclusionAn 8-week personalised health behaviour support programme was feasible for adults with post-COVID syndrome, with good adherence and acceptability rates. Early pilot data from this small sample also suggests meaningful improvements in physical activity, fatigue and respiratory symptoms.Patient or Public ContributionPeople living with post-COVID syndrome were involved from the outset with the study design, review of study documentation and interpretation of the data following completion. Furthermore, several participants have supported the local dissemination of findings following the completion of the study

Witnessing

Geographers have long been concerned with witnessing. Underpinning this broad corpus is a belief that “better” witnessing moves us towards a more progressive, and even liberatory politics. There is an imperative that witnessing itself, if approached sensitively, would provide a meaningful response to realities of violence, harm, and abuse. This chapter asks: How do we make sense of forms of witnessing that have no interest in participating in a restorative project and the reaffirmation of the liberal logic that acts of witnessing often provide? What do we do with registers of testimony that actively refuse and violate liberal sensibilities? This chapter suggests we need to pay greater attention to the figure of the unrepentant witness, and how it redefines the political community who are its audience

ChatGPT versus human essayists: an exploration of the impact of artificial intelligence for authorship and academic integrity in the humanities

Generative AI has prompted educators to reevaluate traditional teaching and assessment methods. This study examines AI’s ability to write essays analysing Old English poetry; human markers assessed and attempted to distinguish them from authentic analyses of poetry by first-year undergraduate students in English at the University of Oxford. Using the standard UK University grading system, AI-written essays averaged a score of 60.46, whilst human essays achieved 63.57, a margin of difference not statistically significant (p = 0.10). Notably, student submissions applied a nuanced understanding of cultural context and secondary criticism to their close reading, while AI essays often described rather than analysed, lacking depth in the evaluation of poetic features, and sometimes failing to properly recognise key aspects of passages. Distinguishing features of human essays included detailed and sustained analysis of poetic style, as well as spelling errors and lack of structural cohesion. AI essays, on the other hand, exhibited a more formal structure and tone but sometimes fell short in incisive critique of poetic form and effect. Human markers correctly identified the origin of essays 79.41% of the time. Additionally, we compare three purported AI detectors, finding that the best, ‘Quillbot’, correctly identified the origin of essays 95.59% of the time. However, given the high threshold for academic misconduct, conclusively determining origin remains challenging. The research also highlights the potential benefits of generative AI’s ability to advise on structuring essays and suggesting avenues for research. We advocate for transparency regarding AI’s capabilities and limitations, and this study underscores the importance of human critical engagement in teaching and learning in Higher Education. As AI’s proficiency grows, educators must reevaluate what authentic assessment is, and consider implementing dynamic, holistic methods to ensure academic integrity

In Vitro Assessment of the Neuro-Compatibility of Fe-20Mn as a Potential Bioresorbable Material for Craniofacial Surgery

Background and Objectives: Spring-assisted surgery is a popular option for the treatment of non-syndromic craniosynostosis. The main drawback of this procedure is the need for a second surgery for spring removal, which could be avoided if a distractor material could be metabolised over time. Iron–Manganese alloys (FeMn) have a good trade-off between degradation rate and strength; however, their biocompatibility is still debated. Materials and Methods: In this study, the neuro-compatibility of Fe-20Mn (wt.%) was assessed using standard assays. PC-12 cells were exposed to Fe-20Mn (wt.%) and stainless steel via indirect contact. To examine the cytotoxicity, a Cell Tox Green assay was carried out after 1, 2, and 3 days of incubation. Following differentiation, a neurite morphological examination after 1 and 7 days of incubation time was carried out. The degradation response in modified Hank’s solution at 1, 3, and 7 days was investigated, too. Results: The cytotoxicity assay showed a higher toxicity of Fe-20Mn than stainless steel at earlier time points; however, at the latest time point, no differences were found. Neurite morphology was similar for cells exposed to Fe-20Mn and stainless steel. Conclusions: In conclusion, the Fe-20Mn alloy shows promising neuro-compatibility. Future studies will focus on in vivo studies to confirm the cellular response to Fe-20Mn

A computational modelling tool for prediction of head reshaping following endoscopic strip craniectomy and helmet therapy for the treatment of scaphocephaly

Endoscopic strip craniectomy followed by helmet therapy (ESCH) is a minimally invasive approach for correcting sagittal craniosynostosis. The treatment involves a patient-specific helmet designed to facilitate lateral growth while constraining sagittal expansion. In this study, finite element modelling was used to predict post-treatment head reshaping, improving our comprehension of the necessary helmet therapy duration. Six patients (aged 11 weeks to 9 months) who underwent ESCH at Connecticut Children's Hospital were enrolled in this study. Day-1 post-operative 3D scans were used to create skin, skull, and intracranial volume models. Patient-specific helmet models, incorporating areas for growth, were designed based on post-operative imaging. Brain growth was simulated through thermal expansion, and treatments were modelled according to post-operative Imaging available. Mechanical testing and finite element modelling were combined to determine patient-specific mechanical properties from bone samples collected from surgery. Validation compared simulated end-of-treatment skin surfaces with optical scans in terms of shape matching and cranial index estimation. Comparison between the simulated post-treatment head shape and optical scans showed that on average 97.3±2.1% of surface data points were within a distance range of -3 to 3mm. The cranial index was also accurately predicted (r=0.91). In conclusion, finite element models effectively predicted the ESCH cranial remodeling outcomes up to 8 months postoperatively. This computational tool offers valuable insights to guide and refine helmet treatment duration. This study also incorporated patient-specific material properties, enhancing the accuracy of the modeling approach. [Abstract copyright: Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Introduced species infiltrate recent stages of succession after glacial retreat on sub-Antarctic South Georgia

Biological invasions are one of the main drivers of global biodiversity decline. At the same time, glacial retreat induced by climate warming is occurring at an alarming rate across the globe, threatening unique taxa and ecosystems. However, we know little about how introduced species contribute to the dynamics of colonisation in newly-deglaciated forelands. To answer this question, detailed inventories of plant and invertebrate communities were undertaken during two summer field seasons in the forelands of three tidewater and three inland glaciers that are retreating on the sub-Antarctic Island of South Georgia. The vascular plant communities present included a large proportion of South Georgia’s native flora. As expected, plant richness and cover increased with time since deglaciation along a deglaciation chronosequence. Introduced plants were well represented in the study sites and two species (Poa annua and Cerastium fontanum) were amongst the earliest and most frequent colonisers of recently-deglaciated areas (occurring on more than 75% of transects surveyed). Introduced arthropods were also present around tidewater glaciers, including an important predatory species (Merizodus soledadinus) with known detrimental impacts on native invertebrate communities. Our study provides a rare and detailed picture of developing novel communities along a deglaciation chronosequence in the sub-Antarctic. Introduced species are able to track glacial retreat on South Georgia, indicating that further local colonisation and spread are inevitable as the region’s climate continues to warm

Goethe’s Platonic Natural Philosophy: How Goethean Science Provides an Alternative Conception of the Cosmos

While popularly known for his works of literature and poetry, Johann Wolfgang von Goethe viewed his lesser-known scientific pieces as his most enduring achievement. I will argue that Goethe’s unique scientific methodology is informed by a metaphysical commitment to a form of Platonism and that Goethe provides an intriguing alternative paradigm that unifies science, philosophy, theology, and ethics. I begin by demonstrating how Goethe’s concept of the Urphänomen offers a Platonic conception of natural beings. I then briefly outline how this alternative scientific approach ultimately derives from his Platonic commitments. Next, I demonstrate the ethical and spiritual implications of Goethean science, establishing that Goethe’s approach bridges the divide between our scientific endeavors and spiritual formation. There is, then, a continued relevance for Goethe in conversations regarding ecological ethics and our perception of nature